ANTIHYPERLIPIDEMIC ACTIVITY OF CASSIA FISTULA BARK USING HIGH FAT DIET INDUCED HYPERLIPIDEMIA
Objective: To study the antihyperlipidemic and anti atherosclerotic activity of Cassia fistula extracts in experimentally induced atherosclerotic rats.
Methods: In this study, the antihyperlipidemic activity of Cassia fistula bark was evaluated by the administration of high fat diet. Atherosclerosis was induced in wistar rats by feeding with high cholesterol diet for 21 d. Oral feeding of cholesterol (500 mg/kg b.w./day) dissolved in coconut oil (0.5 ml/rat/day) caused an elevation in total cholesterol, LDL cholesterol, VLDL cholesterol triglycerides serum of rats.
Results: Administration of Cassia fistula extracts (methanolic and ethyl acetate extract at 500 mg/kg respectively) along with high cholesterol diet reduced the raised serum level of total cholesterol, triglyceride, LDL, VLDL and increased the serum HDL level as compared to the control group (High cholesterol group). Histopathology study of heart has shown decrease in myocardial degeneration and inflammation which may be attributed to the anti atherosclerotic activity of the Cassis fistula bark extracts.
Conclusion: These results suggested that Cassia fistula bark possess significant antihyperlipidemic activity.
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