ANTIHYPERLIPIDEMIC ACTIVITY OF CASSIA FISTULA BARK USING HIGH FAT DIET INDUCED HYPERLIPIDEMIA

  • N. V. L Suvarchala Reddy V Gokaraju Rangaraju College of pharmacy
  • Pooja Raj G. B Department of Pharmacology, Gokaraju Rangaraju College of pharmacy, Nizampet Road, Bachupally, Hyderabad, Telangana State
  • M. Ganga Raju Gokaraju Rangaraju College of pharmacy
  • Sneha J Anarthe Gokaraju Rangaraju College of pharmacy

Abstract

Objective: To study the antihyperlipidemic and anti atherosclerotic activity of Cassia fistula extracts in experimentally induced atherosclerotic rats.

Methods: In this study, the antihyperlipidemic activity of Cassia fistula bark was evaluated by the administration of high fat diet. Atherosclerosis was induced in wistar rats by feeding with high cholesterol diet for 21 d. Oral feeding of cholesterol (500 mg/kg b.w./day) dissolved in coconut oil (0.5 ml/rat/day) caused an elevation in total cholesterol, LDL cholesterol, VLDL cholesterol triglycerides serum of rats.

Results: Administration of Cassia fistula extracts (methanolic and ethyl acetate extract at 500 mg/kg respectively) along with high cholesterol diet reduced the raised serum level of total cholesterol, triglyceride, LDL, VLDL and increased the serum HDL level as compared to the control group (High cholesterol group). Histopathology study of heart has shown decrease in myocardial degeneration and inflammation which may be attributed to the anti atherosclerotic activity of the Cassis fistula bark extracts.

Conclusion: These results suggested that Cassia fistula bark possess significant antihyperlipidemic activity.

 

Keywords: Antihyperlipidemic, Antiatherosclerotic, Cassia fistula, Caesalpiniaceae

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How to Cite
Reddy V, N. V. L. S., P. R. G. B, M. G. Raju, and S. J. Anarthe. “ANTIHYPERLIPIDEMIC ACTIVITY OF CASSIA FISTULA BARK USING HIGH FAT DIET INDUCED HYPERLIPIDEMIA”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 61-64, https://innovareacademics.in/journals/index.php/ijpps/article/view/6351.
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