• Leena Mathew Chemist’s College of Pharmaceutical Sciences, Varikoli p. o, Puthenkruz, Kerala, India
  • D. Kilimozhi Annamalai university
  • S. Parimala Krishnan Annamalai university
  • Mohammed Ismail Moulana Hospital, Madavana


Objectives: In this study it is proposed to analyse the effect of bariatric metabolic surgery on diabetes remission in obese type 2 diabetic patients compared to conventionally treated similar patients.

Methods: A retrospective review, of prospectively collected data base of conventionally treated group and metabolic group were screened from the year 2010-2013 at the study centre for patients satisfying the inclusion criteria. Three follow up data at an interval of three months and a base line value for both group were collected. Primary outcome measures the percentage of patient achieved diabetes remission, i.e. glycosylated haemoglobin (HbA1c)<6 % without active pharmacological therapy at one year and percentage of patients who achieved excess weight loss more than 60 % at one year.

Secondary outcome includes percentage reduction in medication use. Statistics used in the study is student‘t' test, Chi-square and ANOA (Analysis of Variance). The treatment effects were found to be significant to the least significant difference (LSD) at 5% level of significance.

Results: The patients underwent bariatric surgery had a significant improvement in glycemic status (HbA1c<6 %). In conventionally treated group less than 5% achieved HbA1c less than 6.5 % level with active pharmacological therapy. There was an increased use of antidiabetic medication with 2-5% increase in mean body weight in conventional group.

Conclusion: Compared to conventional therapy bariatric surgery markedly improves diabetes and results in discontinuation or marked reduction of anti-diabetic medications in majority of patients treated. So bariatric surgery seems to be a better option for the obese diabetic patients.


Keywords: Bariatric metabolic surgery, Glycosylated hemoglobin, Obesity, Type 2 diabetes, Body Mass Index, Weight loss


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1. Nocca D, Krawczykowsky D. A prospective multicenter study of 163 sleevegastrectomies. Obesity Surgery 2008;18:560-5.
2. Pi-Sunyer X, Blackburn. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes. Diabetes Care 2007;30:1374-83.
3. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R. Medical management of hyperglycemia in type 2diabetes. Diabetes Care 2009;32:193-203.
4. Garber A, Henry R, Ratner R, Garcia-Hernandez PA, Rodriguez-Pattzi H, Olvera Alvarez I, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes. Lancet 2009;373:473-81.
5. Raz I, Hanefeld M, Xu L, Caria C, Williams Herman D, Khatami H, et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006;49;2564 71.
6. DE Mumme, Michal Mathiason, Kara J Kallies, B Shanu N Kothari. Effect of bypass surgery on HbA1c. Surgery Obesity Related Disease 2009;5:4-10.
7. Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ, et al. Weight and type 2 diabetes after bariatric surgery Systematic review and metaanalysis. Am J Med 2009;122:248-56.
8. D’Hondt M, Vanneste S. Laproscopic sleeve gastrectomy as aprocedure for morbid obesity and resolution of comorbidities. Surg Endose 2011;25:2498-504.
9. Dixon JB, Zimmet P, Alberti KG, Rubino F. Bariatric surgery: an IDF statement for obese Type 2 diabetes. Diabetic Med 2011;28:628–42.
10. Kalra S, Unnikrishnan AG. Obesity in India: The weight of the nation. J Med Nutr Nutraceuticals 2012;1:37-41.
11. Inghai A, Sharma P, Jha RK. Effect of sleeve gastrectomy and gastric bypass on diabetic Control in India. Saudi J Obesity 2014;2:59-62.
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How to Cite
Mathew, L., D. Kilimozhi, S. P. Krishnan, and M. Ismail. “EFFECT OF METABOLIC SURGERY ON TYPE 2 DIABETES REMISSION: A MATCHED GROUP ANALYSIS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, July 2015, pp. 206-9, https://innovareacademics.in/journals/index.php/ijpps/article/view/7094.
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