EFFECT OF METABOLIC SURGERY ON TYPE 2 DIABETES REMISSION: A MATCHED GROUP ANALYSIS

  • Leena Mathew Chemist’s College of Pharmaceutical Sciences, Varikoli p. o, Puthenkruz, Kerala, India
  • D. Kilimozhi Annamalai university
  • S. Parimala Krishnan Annamalai university
  • Mohammed Ismail Moulana Hospital, Madavana

Abstract

Objectives: In this study it is proposed to analyse the effect of bariatric metabolic surgery on diabetes remission in obese type 2 diabetic patients compared to conventionally treated similar patients.

Methods: A retrospective review, of prospectively collected data base of conventionally treated group and metabolic group were screened from the year 2010-2013 at the study centre for patients satisfying the inclusion criteria. Three follow up data at an interval of three months and a base line value for both group were collected. Primary outcome measures the percentage of patient achieved diabetes remission, i.e. glycosylated haemoglobin (HbA1c)<6 % without active pharmacological therapy at one year and percentage of patients who achieved excess weight loss more than 60 % at one year.

Secondary outcome includes percentage reduction in medication use. Statistics used in the study is student‘t’ test, Chi-square and ANOA (Analysis of Variance). The treatment effects were found to be significant to the least significant difference (LSD) at 5% level of significance.

Results: The patients underwent bariatric surgery had a significant improvement in glycemic status (HbA1c<6 %). In conventionally treated group less than 5% achieved HbA1c less than 6.5 % level with active pharmacological therapy. There was an increased use of antidiabetic medication with 2-5% increase in mean body weight in conventional group.

Conclusion: Compared to conventional therapy bariatric surgery markedly improves diabetes and results in discontinuation or marked reduction of anti-diabetic medications in majority of patients treated. So bariatric surgery seems to be a better option for the obese diabetic patients.

 

Keywords: Bariatric metabolic surgery, Glycosylated hemoglobin, Obesity, Type 2 diabetes, Body Mass Index, Weight loss

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How to Cite
Mathew, L., D. Kilimozhi, S. P. Krishnan, and M. Ismail. “EFFECT OF METABOLIC SURGERY ON TYPE 2 DIABETES REMISSION: A MATCHED GROUP ANALYSIS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, July 2015, pp. 206-9, https://innovareacademics.in/journals/index.php/ijpps/article/view/7094.
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