NATURAL PRODUCTS AS AN IMPORTANT LEADS FOR DISCOVERY OF NEW ANTITUBERCULAR AGENTS: A REVIEW

  • S. P. Dhanabal JSS College of Pharmacy
  • Namrita Lall University of Pretoria
  • N. Pavithra Project Assistant, DST-Indo-African Project, Department of Pharmacognosy and Phytopharmacy, JSS College of Pharmacy, Ooty
  • M. V. N. L. Chaitanya JSS College of Pharmacy

Abstract

There is a very much need for a discovery of new molecules a potent molecule that can cure tuberculosis and prevent the recurrence. A multidisciplinary approach is required to procure a potent bioactive compound and this includes expertise in the fields of ethnobotany, ethnopharmacology and Phytochemistry. The present communication acts as a bioprospecting source for the drug discovery against tuberculosis, including several anti tubercular agents which is used by used by tribal people and prescribed by THPS which showed a good inhibition rate. Therefore, this review strives to describe the literature on the traditional plants/potent molecules those have been proved to have antimicrobial activity and to provide essential discussion and accelerate the research.

 

Keywords: Tuberculosis, Antitubercular drug discovery, Traditional healers, Drug discovery

Downloads

Download data is not yet available.

References

1. Khatri GR, Thomas R. Frieden. Controlling tuberculosis in India. N Engl J Med 2002;347:1420-5.
2. Acocella G. Human bioavailability studies. Bull Int Union Tuberc Lung Dis 1989;64:38-40.
3. Pillai G. Recent bioequivalence studies on fixed‑dose combination anti‑tuberculosis drug formulations available on the global market. Int J Tuberc Lung Dis 1999;3:309-16.
4. Randall KJ, Spalding JE. Simultaneous carcinoma and tuberculosis of the colon; report of a case and review of the literature. Br J Surg 1946;34:372-5.
5. Miller RE. The co-existence of carcinoma and tuberculosis of the breast and axillary lymph nodes. Am J Surg 1971;121:338-40.
6. Shishoo CJ. Impaired bioavailability of rifampicin in the presence of isoniazid from fixed dose combination FDC formulation. Int J Pharm 2001;228:53-67.
7. Burman WJ. Comparative pharmacokinetics and pharmacodynamics of the rifamycin antibacterials. Clin Pharmacokinet 2001;40:327-41.
8. Ardies CM. Inflammation as cause for scar cancers of the lung. Integr Cancer Ther 2003;2:238-46.
9. Chen-Yi Wu. Pulmonary tuberculosis increases the risk of lung cancer. Cancer 2011;117:618-24.
10. Littman AJ. Prior lung disease and risk of lung cancer in a large prospective study. Cancer Causes Control 2004;15:819-27.
11. Engels EA. Tuberculosis and subsequent risk of lung cancer in Xuanwei, China. Int J Cancer 2009;124:1183-7.
12. Andrzej Pawlowski. Tuberculosis and HIV Co-Infection. PLoS Pathog 2012;8:1-7.
13. Rambir Singh. Anti-mycobacterial screening of five Indian medicinal plants and partial purification of active extracts of Cassia sophera and Urtica dioica. Asian Pac J Trop Dis 2013;3:366-71.
14. Marina Zadra. In vitro evaluation of the antimicrobial and antimycobacterial activities of Solanum guaraniticum A. St.-Hil. Leaves J Appl Pharm Sci 2013;3:19-23.
15. Stanley Mukanganyama. Antimycobacterial activity of diospyrin and its derivatives against Mycobacterium aurum. Res Pharm 2012;2:1-13.
16. MR Pradeep kumar. Evaluation of antibacterial and antitubercular activity of Phaseolus vulgaris Linn., seeds. Int J Pharma Bio Sci 2014;53:219-4.
17. Allan Patrick G Macabeo, Amier Dayle A Lopez. Antitubercular and cytotoxic constituents from goniothalamus gitingensis. Rec Nat Prod 2013;8:41-5.
18. Soundhari C, Rajarajan S. In vitro screening of lyophilised extracts of Alpinia galanga and oldenlandia umbellata for antimycobacterial activity. Int J Life Sci Biotechnol Pharma Res 2013;46:427-32.
19. Sivakumar, G Jayaraman. Anti-tuberculosis activity of commonly used medicinal plants of south India. J Med Plant Res 2011;531:6881-4.
20. Jaya Sehgal. Anti-tubercular activity of fruits of prunus armeniaca. Int J Pharm Bio Sci 2010;12:1-4.
21. Chandrasekar Balachandran. Antimycobacterial and cytotoxic A549 properties of vasicinone isolated from adhatoda vasica L. Asian Pac J Trop Biomed 2012;1:1-4.
22. Gautam AH. Review of herbal plants useful in tuberculosis. Int Res J Pharm 2012;37:62-7.
23. Vikrant Arya. A review on anti-tubercular plants. Int J PharmTech Res 2011;32:872-80.
24. Bernaitis. Effects of selective medicinal plants against multi drug resistance mycobacterium tuberculosis strains. Res J Pharm Biol Chem Sci 2013;43:812-7.
25. EN Murthy. Ethno medicinal plants used by gonds of Adilabad district, Andhra Pradesh, India. Int J Pharm Life Sci 2012;310:2034-43.
26. Manoj Goyal. Review on ethnomedicinal uses, pharmacological activity and phytochemical constituents of ziziphus mauritania. Scope Med 2012;22:107-16.
27. Usha devi. Assessment of ethnomedicinal plants in shivalik hills of northwest himalaya, India. Am J Ethnomed 2014;14:186-205.
28. M Kalaiselvan. Ethnobotanical studies on selected wild medicinal plants used by irula tribes of bolampatty valley, Nilgiri biosphere reserve, southern western ghats, India. Asian J Pharm Clin Res 2014;71:22-6.
29. J Koteswara Rao. Ethnomedicine of the Gadabas, a primitive tribe of Visakhapatnam district, Andhra Pradesh. Int Multidiscip Res J 2011;12:10-14.
30. Jitu Buragohain. Ethnomedicinal plants used by the ethnic communities of tinsukia district of Assam, India. Recent Res Sci Technol 2011;39:31-42.
31. Yogesh Chaturvedi. Ethnomedicinal study of plants with special reference to bacterial diseases in kondar and saur tribes of district chhatarpur, Madhaya Pradesh, India. World J Pharm Pharm Sci 2014;37:1899-904.
32. Prabhat Kumar. Ethnomedicinal plant resources of mizoram, India: implication of traditional knowledge in health care system. Ethnobotanical Leaflets 2010;14:274-305.
33. Patel SK. Ethnomedicinal plants used by the tribes in bhiloda taluka of sabarkantha district, Gujarat. Indian J Adv Plant Res 2014;16:33-6.
34. Priti Kumari. Indigenous uses of threatened ethno-medicinal plants used to cure different diseases by ethnic people of almora district of western himalaya. Int J Ayurveda Altern Med 2012;24:661-78.
35. Amuthavalluvan. Ethno medicinal practices and traditional healing system of kattunayakan in tamilnadu: an anthropological study. Int Multidiscip Res J 2011;17:47-51.
36. V Madhu. Ethnomedicinal uses of leaf preparations in adilabad district, Andhra Pradesh, India. Ethnobot Leaflets 2009;13:1337-47.
37. Tukaram. Lesser known ethnomedicinal plants of hingoli district, Maharashtra, India. Int J Ethnobiol Ethnomed 2014;11:1-4.
38. Pankaj. Ethnomedicinal plants used in the health care systems of tribes of dantewada, Chhattisgarh, India. Am J Plant Sci 2014;5:1632-43.
39. Alok. Use of ethnomedicinal plants by natives of bargarh district of orissa, India. Ethnobot Leaflets 2010;14:889-97.
40. Sathyavathi. Folklore medicinal practices of badaga community in nilgiri biosphere reserve, Tamilnadu, India. Int J Pharm Res Dev 2011;32:50-63.
41. Liang WU. Systematic phytochemical investigation of abies spectabilis. Chem Pharm Bull 2010;58:1646-9.
42. Herbs. The plants for a future. Available from: URL: http: //www.naturalmedicinalherbs.net/herbs/a/abies-spectabilis=himalayan-fir.php. [Last accessed on 12 Jan 2015].
43. Anwesa Bag. The development of Terminalia chebula retz. Combretaceae in clinical research. Asian Pac J Trop Med 2013;33:244-52.
44. Kandasamy. Evaluation of antibacterial efficacy of phyto fabricated silver nanoparticles using mukia scabrella musumusukkai against drug resistance nosocomial gram negative bacterial pathogens. Colloids Surf B 2012;1041:282-8.
45. G F Gonzales. Effect of lepidium meyenii maca, a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men. J Endocrin 2003;176:163-8.
46. Indian Herbs. Available from: URL: http: //www. iloveindia. com/indian-herbs/cinnamon.html. [Last accessed on 17 Jan 2015].
47. Diego Francisco. Clove Syzygium aromaticum: a precious spice. Asian Pac J Trop Biomed 2014;42:90-6.
48. Malik. Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders. J Med Food 2010;135:1086-96.
49. Gyanunlimited. A hub of Alternative medicine and holistic health. Available from: URL: http: //www.gyanunlimited.com/ health/top-health-and-medicinal-benefits-of-black-pepper-amazing-fitness-tips/2363/. [Last accessed on 20 Jan 2015].
50. Rekha. Handbook of indices of food quality and authenticity. Woodhead Publishers 1997;152:395-02.
51. Poonam. Ferula asafoetida: traditional uses and pharmacological activity. Pharmacogn Rev 2012;612:141-6.
52. Kumar. Phytochemical screening and antioxidant potency of Adhatoda vasica and Vitex negundo. Bioscan 2013;82:727-30.
53. Soni. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids. Indian J Pharm Sci 2008;701:36-42.
54. Kirti Sinha. Tinospora cordifolia Guduchi, a reservoir plant for therapeutic applications: a review. Indian J Traditional Knowledge 2004;33:257-70.
55. Om prakash. Oleoresin guggul: a review of the medicinal evidence for its therapeutic properties. Int J Res Ayur Pharm 2012;31:15-21.
56. Ruitang Deng. Therapeutic effect of guggul and its constituent guggulsterone: cardiovascular benefits. Cardiovasc Drug Rev 2007;254:375-90.
57. Muchtaridi. Identification of compounds in the essential oil of nutmeg seeds myristica fragrans houtt. That inhibit locomotor activity in mice. Int J Mol Sci 2010;11:4771-81.
58. MT Olaleye. Antioxidant properties of myristica fragrans houtt and its effect on selected organs of albino rats. Afr J Biotechnol 2006;513:1274-8.
59. Chandra Mohan. Phytochemical, GC-MS analysis and antibacterial activity of a medicinal plant acalypha indica. Int J Pharmatech Res 2012;43:1050-4.
60. Zahir Hussain. GC-MS analysis and antibacterial evaluation of Acalypha indica. Asian J Plant Sci Res 2013;36:46-9.
61. Linn Narayan, CS Chanotia. Phytochemical and pharmacological profile of leaves of aegle marmelos. Altern Med Nutra 2009;13:144-50.
62. Ganesh Sharma. Medicinal values of bael aegle marmelos corr: a review. Int J Curr Pharm Rev Res 2011;21:12-22.
63. Devendran, Balasubramanian. Qualitative phytochemical screening and GC-MS analysis of Ocimum sanctum L. leaves. Asian J Plant Sci Res 2011;14:44-8.
64. Priyabrata Pattanayak. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: an overview. Pharmacogn Rev 2010;47:95-105.
65. NM Reddy, Rajasekhar Reddy. Solanum xanthocarpum chemical constituents and medicinal properties: a review. Scholars Acad J Pharm 2014;32:146-9.
66. Bhawana Bhatt. Chemical constituents of solanum xanthocarpum. J Chem Pharm Res 2011;33:176-81.
67. Joao. Chemical characterization of chestnut cultivars from three consecutive years: chemometrics and contribution for authentication. Food Chem Toxicol 2012;50:2311–7.
68. Maria Do Carmo. Primary and secondary metabolite composition of kernels from three cultivars of Portuguese chestnut castanea sativa Mill. at different stages of industrial transformation. J Agric Food Chem 2007;559:3508-16.
Statistics
669 Views | 792 Downloads
How to Cite
Dhanabal, S. P., N. Lall, N. Pavithra, and M. V. N. L. Chaitanya. “NATURAL PRODUCTS AS AN IMPORTANT LEADS FOR DISCOVERY OF NEW ANTITUBERCULAR AGENTS: A REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 2-7, https://innovareacademics.in/journals/index.php/ijpps/article/view/7646.
Section
Review Article(s)