• Shawn Tomy RVS College of Pharmaceutical Sciences, Coimbatore
  • Sam Johnson Udaya Chander J RVS College of Pharmaceutical Sciences, Coimbatore, Tamil Nadu, India
  • Sandra Celine RVS College of Pharmaceutical Sciences, Coimbatore
  • Ujwala Tk RVS College of Pharmaceutical Sciences, Coimbatore
  • Cs Kandasamy RVS College of Pharmaceutical Sciences, Coimbatore
  • P Arulraj RVS College of Pharmaceutical Sciences, Coimbatore
  • R Venkatanarayanan RVS College of Pharmaceutical Sciences, Coimbatore


Objective: The present study investigates the efficacy of DiaKure, a poly herbal formulation composed of powder of different herbs on blood glucose level of normal and diabetic rats.

Methods: The raw materials were collected made it into a powder formulation. Streptozotocin 60 mg/kg was administered as a single i. p. Injection for induction of type 1 diabetes. After one week of streptozotocin injection, animals showing glycosuria (fasting blood sugar level>200 mg/dL) were considered as diabetic. The hypoglycemic activity and glucose tolerance test were studied in normal and Streptozotocin-induced diabetic rats after administration of DiaKure at a dose of 300 mg/kg. Blood glucose was determined by a glucose monitor.

Results: At a dose of 200 and 300 mg/kg p. o., DiaKure showed a hypoglycemic effect at a varying degree of significance (P<0.05-0.001) in normal rats in comparison with the respective control group. Maximum effect of DiaKure treatment in the glucose tolerance test occurred at 120thminute of glucose administration in normal rats.

Conclusion: The results indicate significant hypoglycemic activity of DiaKure in male albino rats.


Keywords: Polyherbal, Glucose tolerance test, Dia Kure, Hypoglycemic, Streptozotocin


Download data is not yet available.


1. Anonymous. Diabetes now a global threat gets own day. Sunday Times India 2006;24:11.
2. Gerstain HC, Santaguida P, Raina P, Morrison KM. Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies. Diabetes Res Clin Pract 2007;78:305-1 2.
3. Bhatt N. Ayurvedic drug industry: challenges of today and tomorrow, Proceedings of the first national symposium of Ayurvedic drug industry, organized by ADMA, New Delhi; 1998.
4. Sharma N, Sharma M, Bindal MC. Potential antidiabetic herbal drugs. A comparative review of marketed products. Res J Pharmacogn Phytochem 2010;2:115-21.
5. Keshri Umashanker PD, Satish Chandra, Janardan Sharma. Antidiabetic efficacy of ethanolic extract of Holarrhena antidysenterica seeds in streptozotocin–induced diabetic rats and its influence on certain biochemical parameters. J Drug Delivery Ther 2012;2:159-62.
6. Shivanisaini, Sunil Sharma. Antidiabetic effect of helianthus annuus seeds ethanolic extract in streptozotocin-nicotinamide induced type 2 diabetes mellitus. Int J Pharm Pharm Sci 2013;2:382-7.
7. Shirwaikar A, Rajendran K. Effect of aqueous bark extract of Garugapinnata Roxb. in streptozotocin–nicotinamide induced type-II diabetes mellitus. J Ethnopharmacol 2006;107:285-90.
8. Mohammed Fazil Ahmed, Syed Mohammed Kazim, Syed Safiullah Ghori, Syeda Sughramehjabeen, Shaik Rasheed Ahmed, Shaik Mehboob Ali, et al. Antidiabetic activity of Vinca rosea extracts in alloxan-induced diabetic rats. Int J Endocrinol 2010;2:1-6.
9. A Navitha, DA Helen Sheeba, C Ramesh, M Sartaj Banu. Hypoglycemic and anti-diabetic activity of ethanolic extract of Catharanthus pusillus (murray) g. don. IOSR J Pharm 2012;4:17-21.
10. Vijayalakshmi M, Noor A, Gunasekaran S, Manickam AS. Antidiabetic activity of Aloe vera and histopathology of organs in Streptozotocin induced diabetic rats. Curr Sci 2008;94:1070.
11. Sanjay Kumar Karan, Dilipkumar Pal, Sagar Kumar Mishra. Anti-hyperglycaemic effect of Vetiveria zizanioides (L.) nash root extract in alloxan induced diabetic rats. Asian J Chem 2013;3:1555-7.
12. Teeraporn Katisart. Transient receptor potential function in bladder from control and streptozotocin treated rats. Ph. D Thesis, Faculty of Health and Human Sciences, University of Hertfordshire, UK; 2011.
13. A Akbarzadeh, D Norouzian, MR Mehrabi, Sh Jamshidi, A Farhangi, A Allah Verdi, et al. Induction of diabetes by streptozotocin in rats. Indian J Clin Biochem 2007;22:60-4.
14. Pries E, Garrity L, Kays N, McDaniel P. 0023-Growth hormone treatment of a child with growth hormone deficiency, type I diabetes and chronic steroid use. J Pediatric Nursing 2006;21:1-6.
637 Views | 694 Downloads
How to Cite
Tomy, S., S. J. U. Chander J, S. Celine, U. Tk, C. Kandasamy, P. Arulraj, and R. Venkatanarayanan. “ANTI-DIABETIC EFFECT OF POLYHERBAL FORMULATION IN OGTT AND STREPTOZOTOCIN-INDUCED DIABETIC RAT MODEL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 216-9,
Original Article(s)