ANTI-DIABETIC EFFECT OF POLYHERBAL FORMULATION IN OGTT AND STREPTOZOTOCIN-INDUCED DIABETIC RAT MODEL

  • Shawn Tomy RVS College of Pharmaceutical Sciences, Coimbatore
  • Sam Johnson Udaya Chander J RVS College of Pharmaceutical Sciences, Coimbatore, Tamil Nadu, India
  • Sandra Celine RVS College of Pharmaceutical Sciences, Coimbatore
  • Ujwala Tk RVS College of Pharmaceutical Sciences, Coimbatore
  • Cs Kandasamy RVS College of Pharmaceutical Sciences, Coimbatore
  • P Arulraj RVS College of Pharmaceutical Sciences, Coimbatore
  • R Venkatanarayanan RVS College of Pharmaceutical Sciences, Coimbatore

Abstract

Objective: The present study investigates the efficacy of DiaKure, a poly herbal formulation composed of powder of different herbs on blood glucose level of normal and diabetic rats.

Methods: The raw materials were collected made it into a powder formulation. Streptozotocin 60 mg/kg was administered as a single i. p. Injection for induction of type 1 diabetes. After one week of streptozotocin injection, animals showing glycosuria (fasting blood sugar level>200 mg/dL) were considered as diabetic. The hypoglycemic activity and glucose tolerance test were studied in normal and Streptozotocin-induced diabetic rats after administration of DiaKure at a dose of 300 mg/kg. Blood glucose was determined by a glucose monitor.

Results: At a dose of 200 and 300 mg/kg p. o., DiaKure showed a hypoglycemic effect at a varying degree of significance (P<0.05-0.001) in normal rats in comparison with the respective control group. Maximum effect of DiaKure treatment in the glucose tolerance test occurred at 120thminute of glucose administration in normal rats.

Conclusion: The results indicate significant hypoglycemic activity of DiaKure in male albino rats.


 

Keywords: Polyherbal, Glucose tolerance test, Dia Kure, Hypoglycemic, Streptozotocin

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How to Cite
Tomy, S., S. J. U. Chander J, S. Celine, U. Tk, C. Kandasamy, P. Arulraj, and R. Venkatanarayanan. “ANTI-DIABETIC EFFECT OF POLYHERBAL FORMULATION IN OGTT AND STREPTOZOTOCIN-INDUCED DIABETIC RAT MODEL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 216-9, https://innovareacademics.in/journals/index.php/ijpps/article/view/7658.
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