• Iraj Salehi Department of Physiology, School of Paramedicine,Hamadan University of Medical Sciences, Hamadan
  • Aliasghar Vahidinia Department of Nutrition and Biochemistry, Medical Faculty, Hamadan University of Medical Sciences, Hamadan
  • Abbas Bakhtiari Department of Anatomy, Medical Faculty, Isfahan University of Medical Sciences, Isfahan
  • Pouria Mohammadi Department of Molecular Medicine & Genetics, Medical Faculty, Hamadan University of Medical Sciences, Hamadan
  • Anil Sukumaran Division of Periodontics, College of Dentistry, King Saud University
  • Seyed-mostafa Hosseini-zijoud Baqiyatallah University of Medical Sciences, Tehran, Iran


Objective: Garlic has a protective effect against hyperlipidemia and ghee in diet is considered as a risk factor for hyperlipidemia. We examined the effects of fresh garlic administration on body weight, lipid profiles and plaque formation in the male rats fed with a high ghee diet.

Methods: Twenty-four male Wistar rats were randomly divided into 3 groups of 8. The control group consumed an ordinary diet, Group 2 received the 31% ghee pellets (high ghee diet) and group 3 received the 8% garlic+31% ghee pellets. After 9 mo, serum levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and atherosclerotic index (AI) were examined. Changes in body weight, daily food intake and plaque formation also were assayed in this survey.

Results: The high ghee diet induced the significant increase (P<0.05) in serum concentrations of TC, TG and HDL-C, and a decrease in LDL-C concentration (group 2). While fresh garlic increased TG (P<0.05) and HDL-C levels and declined TC and LDL-C in treated rats (group 3). Meanwhile, ghee and garlic showed a favorable effect in reducing AI (P<0.05). No histopathological changes were observed in the Aorta of the rats.

Conclusion: Evidence obtained from this study indicates that ghee and fresh garlic has potential effects in the prevention and control of hyperlipidemia complications and are beneficial when taken as a dietary supplement.




Keywords: Ghee, Fresh Garlic, Lipid profile, Rat


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How to Cite
Salehi, I., A. Vahidinia, A. Bakhtiari, P. Mohammadi, A. Sukumaran, and S.- mostafa Hosseini-zijoud. “THE EFFECT OF FRESH GARLIC ON THE LIPID PROFILE AND ATHEROSCLEROSIS DEVELOPMENT IN MALE RATS FED WITH A HIGH GHEE DIET”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 9, Aug. 2015, pp. 486-90,
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