IN VITRO RELEASE KINETICS OF SIMVASTATIN FROM METHYL CELLULOSE GEL

  • Swaminathan Rajendran Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, No.1 Ramachandra Nagar, Porur, Chennai 600116, India
  • Ramesh S Sri Ramachandra University
  • Sathesh Kumar Sri Ramachandra University
  • Suresh Ranga Rao Sri Ramachandra University

Abstract

Objective: a) To estimate the ideal percentage of polymer (methyl cellulose) and the drug (simvastatin) for controlled release gel. b) To evaluate the release kinetics and physical property.

Methods: Drug polymer interaction was studied using Differential Scanning Calorimeter (DCS) and Fourier Transform Infrared Spectroscopy (FTIR). Simvastatin powder was hydrolysed to active simvastatin hydroxyl acid. Nine gel formulations using three different concentrations of simvastatin (SMV) (1.2%, 1.7% and 2.2%) and three concentration of methyl cellulose (MC) (4%, 5% and 6%) were prepared. Drug release kinetics of 9 formulations was assessed using open end tube method with the dialysis membrane. The physical property was studied using rheometer.

Results: DSC and FITR results showed no drug polymer interaction. The release kinetics of all nine formulations was in a controlled manner. 4% MC 2.2% SMV, 5% MC 2.2% SMV, 6% MC 2.2% SMV showed controlled drug release compared to other six formulations. The pH of all the nine formulations ranged between 6.21–6.25. The drug content of each formulation was above 97.9%.

Conclusion: This study showed that increase in polymer concentration in the gel increased the controlled release of the drug and addition of the drug to the gel decreased the viscosity of the gel.

 

Keywords: Simvastatin, Methyl cellulose, Controlled release gel

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How to Cite
Rajendran, S., R. S, S. Kumar, and S. R. Rao. “IN VITRO RELEASE KINETICS OF SIMVASTATIN FROM METHYL CELLULOSE GEL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 106-10, https://innovareacademics.in/journals/index.php/ijpps/article/view/7711.
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