• Shereen A. Sabry Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig, University, Zagazig, Egypt
  • Azza A. Hasan Zagazig, University
  • Marwa H. Abdallah Zagazig, University


Objective: The aim of the present work was to formulate a controlled release dosage form of water soluble drug such as Nizatidine to increase its gastric retention in the stomach and consequently, enhance its absorption and improve its bioavailability.

Methods: Microballoons were prepared by emulsion non solvent evaporation method using ethyl cellulose 7 CP in different ratios. The prepared microballoons were evaluated for yield percentage, entrapment efficiency, in vitro buoyancy and in vitro dissolution.

Results: Results showed that as drug to polymer ratio increased from 1:1 to 1:5 yield percentage, entrapment efficiency, in vitro buoyancy increased from 70.4+1.5 to87.2+1.8, from 71.5+2.1 to 90.2+2.6 and from 82.1+3.2 to 93.2+2.6, respectively, while the amount of drug released decreased from 88.1+2.1 to 68.9+1.8. When stirring rate increased from 800 rpm to 1600 rpm, the three parameters decreased from 93.2+2.7 to 81.5, from 96.4+3.5 to 82.6+1.7 and from 97+5.4 to 88.2+4.1, respectively, while the amount released increased from 63.1+2.6 to 73.8+1.2. When Span 80 concentrations increased from 0.1% to 2% the three parameters decreased from 95.2+2.6, to 81.6+3.2, from 97.6+1.8 to 82.4+1.8 and from 97.3+5.2 to 89.1+4.6, respectively, and the amount released percentage increased from 61.2+2.6 to 76.1+1.6. All drug release showed Higuchi diffusion models. The increase in the mean Tmax and the decrease in the mean Cmax of microballoons compared to the plain drug indicate a sustained release of microballoons and reflects a high improvement in its bioavailability.

Conclusion: It is evident from this study that microballoons are promising gastric prolonging the delivery system for nizatidine and have good stability.


Keywords: Microballoons, Gastro retentive system, Nizatidine, Buoyancy


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How to Cite
Sabry, S. A., A. A. Hasan, and M. H. Abdallah. “GASTRORETENTIVE NIZATIDINE LOADING MICROBALLOONS FOR TREATMENT OF PEPTIC ULCER”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 220-5,
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