MICROWAVE ASSISTED GREEN SYNTHESIS OF PHARMACEUTICALLY IMPORTANT DIHYDROPYRIMIDINONES IN FRUIT JUICE MEDIUM
Objective: The objective of this research project was to perform the green synthesis of a series of Dihydropyrimidinone (DHPM) derivatives which are having immense importance in biological and pharmaceutical science, via microwave assisted Biginelli reaction in fruit juice medium.
Methods: Urea and ethyl acetoacetate were made to react with different electron rich as well as electron deficient aromatic aldehydes in various fruit juice medium under microwave irradiation. After successful completion of the reaction the crude product was precipitated out of the reaction medium and after re-crystallization of the crude product the pure desired DHPMs were obtained with quite good percentage of yield.
Results: It was observed that our green Biginelli reaction was completed successfully within few minutes duration and the microwave assisted Biginelli reaction in fruit juice medium was much faster, greener and cleaner compared to that of room temperature Biginelli reaction in the same fruit juice medium. The acidity of the fruit juices and the electronic effect of the aromatic aldehydes have shown significant influence on the rate of reaction.
Conclusion: Thus an efficient, green, cost-effective and eco-friendly method has been developed and reported for the very first time for microwave assisted synthesis of dihydropyrimidinone using some common fruit juices as reaction medium. The fruit juices have served as the solvent cum catalyst in these Biginelli reactions. Our current approach of synthesizing DHPM via microwave assisted Biginelli reaction in fruit juice medium has given a new direction in the field of green chemistry.
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