• Voleti. Vijaya Kumar Department of Pharmaceutics, Rao’s College of Pharmacy, Nellore, A. P, India
  • Chittiboyina. Niroosha Rao’s College of Pharmacy
  • M. Ravi Rao’s College of Pharmacy


Imidapril, Mouth dissolving tablets, Sodium starch glycolate, Croscarmellose sodium, Kyron T314


Objective: The aim of this work was preparing once daily mouth disintegrating tablets to handle easily for adult hypertensive patients who have difficulty in swallowing.

Methods: Imidapril mouth dissolving tablets (MDTs) were prepared by direct compression method using different concentrations of synthetic super disintegrants namely Sodium starch glycolate, Croscarmellose sodium & Kyron T-314. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, content uniformity, disintegration time and In-vitro dissolution studies.

Results: The micropolitics study indicates that all formulations were of acceptable to good flowability. Tablet hardness and friability indicated that the prepared formulations were having good mechanical strength. The most satisfactory formulation F5 containing Sodium starch glycolate showed minimum disintegration time of 19 s and released a maximum amount of drug in 30 min in phosphate buffer 6.8pH, by an appropriate combination of excipients. The optimized F5 formulation containing Sodium starch glycolate was found to be stable during stability studies conducted for 3 mo as per International Conference on Harmonization (ICH) guidelines.

Conclusion: The present study conclusively proved that Imidapril MDTs could be successfully developed using various super disintegrants. The prepared tablets gave promising results with respect to the faster release of Imidapril. Further clinical studies are suggested to confirm the ability of the best-achieved system to avoid the first pass metabolism of Imidapril and improve patient compliance.



Download data is not yet available.


Shyamala B, Narmada GY. Rapid dissolving tablets: a novel dosage form. Indian Pharm 2002;13:9-12.

Kuchekar BS, Bhise SB, Arungam V. Design of mouth dissolving tablets. Indian J Pharm Educ 2005;35 Suppl4:150-2.

Habib W, Khankari R, Hontz J. Fast dissolve drug delivery systems. Crit Rev Ther Drug Carrier Syst 2000;17:61-72.

Kaushik D, Dureja H, Saini TR. Mouth dissolving tablets: a review. Indian Drugs 2004;41:187-93.

Dobetti L. Fast melting tablets: developments and technologies. Pharm Technol Drug Delivery 2001;1:44-50.

Deepak K. Orally disintegrating tablets. Tablets Capsule 2004;7:30-5.

Parakh SR, Gothoskar AV. A review of mouth dissolving tablet technologies. Pharm Tech 2003;27:92-8.

Rajesh M, Kumar BK, Sundaram SM, Pippala MK. Formulation and evaluation of Metformin Hydrochloride microspheres by solvent evaporation method. Int J Pharm Res Scholars 2013;2:121-7.

Rai Rajesh Roshan, Chirra Pavithra, Thanda Venkataramudu. Fast dissolving tablets: a novel approach to drug delivery–a review. Int J Preclin Pharm Res 2012;3:23-32.

Shaikh S. Formulation and evaluation of orodispersible tablets of piroxicam. J Pharm Cosmetol 2010;1:2-8.

Lalla JK, Mamania HM. Fast dissolving rofecoxib tablets. Indian J Pharm Sci 2004;59:23-6.

Panigrahi R, Behera S, Panda C. a review on fast dissolving tablets. Web Med Central Pharm Sci 2010;1:1-15.

Mahaveer Pr Khinchi. Orally disintegrating tablets: a future prospectus. Int J Adv Pharm Biol Sci 2012;3:71-9.

Nandgude TD, Saifee M, Bhise KS. Formulation and evaluation of fast disintegrating tablets of diphenhydramine tannate. Am J Pharm 2006;1:41-5.



How to Cite

Kumar, V. V., C. Niroosha, and M. Ravi. “COMPARATIVE FORMULATION, EVALUATION AND OPTIMIZATION OF IMIDAPRIL MOUTH DISSOLVING TABLETS USING DIFFERENT SYNTHETIC SUPERDISINTEGRATING AGENTS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 1, Jan. 2016, pp. 150-6,



Original Article(s)