COMPARATIVE STUDY OF KANAMYCIN AND CAPREOMYCIN ON SERUM POTASSIUM LEVEL OF MULTIDRUG RESISTANCE TUBERCULOSIS PATIENTSAT A HOSPITAL IN BANDUNG, INDONESIA
Keywords:Second line Injectable Antituberculosis, Adverse Drug Reaction, Hypokalemia
Objective: Kanamycin and capreomycin are the second lines injectable ant tuberculosis used in therapy regimen of multidrug resistance tuberculosis (MDR TB) in Indonesia. Both have effects on serum potassium levels and cause hypokalemia. The aim of this study is to compare and evaluate the effects of kanamycin and capreomycin on serum potassium levels of MDR TB patient.
Methods: This was a retrospective and concurrent cohort study with intention-to-treat analysis on MDR TB patients during 2014 at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. The patients were divided into two groups, one group received kanamycin regimen. Meanwhile, the other group received capreomycin regimen. Serum potassium level, the incidence of hypokalemia and the classification of its severity were compared monthly for five months of the therapy.
Results: In the first two months, capreomycin significantly decreased serum potassium level stronger than kanamycin (2.95 mEq/l vs. 3.82 mEq/l, P<0.001 in the first month and 2.85 mEq/l vs. 3.81 mEq/l, P<0.001 in the second month). Before five months, the number of enabled patients to follow up decline which is caused by hypokalemia in capreomycin group was60.0% while in kanamycin group is 0.0%.
Conclusion: Capreomycin has a stronger effect on decreasing serum potassium level compared to kanamycin, and it causes hypokalemia.
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