STUDY ON PREVALENCE OF ADVERSE DRUG REACTIONS IN PATIENTS SUFFERING FROM TUBERCULOSIS IN A TERTIARY CARE HOSPITAL
Objective: To study the prevalence of ADRs associated with the use of anti-tubercular drugs in patients with tuberculosis in a tertiary care hospital.
Methods: A prospective observational and active surveillance study was conducted in the department of pulmonology and DOTS Centre in Owaisi Hospital and Research Centre over a period of 6 mo after the study was approved by IRB. The patients who gave informed consent were included in the study and their information was analysed after being recorded in a data collection form.
Results: Descriptive statistical analysis was carried out to generate results, the continuous measurement being presented as mean standard deviation (min-max) and categorical measurement presented in number (%). The results showed the prevalence of ADRs to be 69%. The prevalence of ADRs was more in females (55%) than in males (45%) and 75.9% of them reporting more than 1 ADR. ADRâ€™s affecting the skin and appendages were high (23.56%) while ADRâ€™s affecting gastrointestinal system (19.28%), the hepatic system (4.28%), the musculoskeletal system (15.7%), Central and peripheral nervous system (7.85%), Vision (0.7%) were comparatively less.
Conclusion: The study highlighted the importance of developing strategies to ameliorate ADRs both to improve the quality of patient care and to control TB safely.Â
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