• Juan Fernando Pinillos University of Antioquia
  • Laura Rojas University of Antioquia
  • Cecilia Gallardo Department of Pharmacy, University of Antioquia, Medellin, Colombia


Objective: The objective of this research was to assess for the first time the adsorption of erlotinib (ERL) in three types of multi walled carbon nanotubes, as feasible alternative method to removal antineoplastic from wastewater.

Methods: Both multi walled carbon nanotubes without modification (pristine-CNT) and modified carbon nanotubes by oxidation (CNT-COOH) and amination (CNT-NH2) were used as adsorbents. They were characterized by Transmission electron microscopy, Raman spectroscopy, FT-IR spectroscopy, and Thermogravimetric analysis. In addition, the stability of CNTs suspensions were monitored. The ERL residual concentration in the equilibrium, from the bath adsorption, experiments was quantified by HPLC. The experiment data were fitted to Langmuir and Freundlich models.

Results: The characterization showed that the surface of pristine-CNT was modified. Different sedimentation behavior was observed in the three types of CNTs. ERL adsorption followed the Langmuir model for CNT-NH2, Freundlich model for CNT-COOH and did not fit any models for pristine-CNT. Adsorption parameters were favoured with the functionalization of CNTs, which can be explained by properties of ERL and surface chemistry of CNTs.

Conclusion: It was found that CNTs have a high capacity of adsorption of ERL, indicating the potential of CNTs to removal this antineoplastic drug from hospital wastewater.


Keywords: Erlotinib, CNT, Adsorption isotherm, Antineoplastic


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How to Cite
Pinillos, J. F., L. Rojas, and C. Gallardo. “ADSORPTION OF ERLOTINIB TO MULTIWALLED CARBON NANOTUBES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 1, Dec. 2015, pp. 399-03,
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