EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY OF STEM BARK EXTRACTS OF MESUA FERREA LINN.

  • Prathima Ranganathaiah Kuvempu, University,
  • Manjunatha Hanumanthappa Department of PG Studies and Research in Biotechnology and Bioinformatics, Kuvempu, University, Shankaraghatta 577451, Karnataka, India
  • Krishna Venkatarangaiah Kuvempu, University,

Abstract

Objective: Phytochemical evaluation and in vitro anti-inflammatory activity of stem bark extracts of Mesua ferrea Linn.

Methods: Petroleum ether, chloroform, and 80% ethanol extracts were used for in-vitro bioassays: such as Human red blood cells membrane stabilization, protein inhibitor, inhibition of egg albumin and anti-lipoxygenase assay to evaluate their anti-inflammatory potential.

Results: Phytochemical analysis revealed the presence of phenols, flavonoids, alkaloids, steroids, saponins, tannins, glycosides, and terpenoids. The petroleum ether, chloroform, and 80% ethanol extracts showed significant reduction in inflammation at different 100, 200 and 500μg/ml compared to standard drug indomethacin (100μg/ml).

Conclusion: Based on the results, it can be concluded that the 80% ethanol extract of stem bark of Mesua ferrea Linn. (M. ferrea) exhibited significant anti-inflammatory activity compared to petroleum ether and chloroform extracts.

 

Keywords: Mesua ferrea Linn. Phytochemicals, Anti-inflammatory

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Ranganathaiah, P., M. Hanumanthappa, and K. Venkatarangaiah. “EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY OF STEM BARK EXTRACTS OF MESUA FERREA LINN.”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 2, Feb. 2016, pp. 173-7, https://innovareacademics.in/journals/index.php/ijpps/article/view/9971.
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