EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY OF STEM BARK EXTRACTS OF MESUA FERREA LINN.


Prathima Ranganathaiah, Manjunatha Hanumanthappa, Krishna Venkatarangaiah

Abstract


Objective: Phytochemical evaluation and in vitro anti-inflammatory activity of stem bark extracts of Mesua ferrea Linn.

Methods: Petroleum ether, chloroform, and 80% ethanol extracts were used for in-vitro bioassays: such as Human red blood cells membrane stabilization, protein inhibitor, inhibition of egg albumin and anti-lipoxygenase assay to evaluate their anti-inflammatory potential.

Results: Phytochemical analysis revealed the presence of phenols, flavonoids, alkaloids, steroids, saponins, tannins, glycosides, and terpenoids. The petroleum ether, chloroform, and 80% ethanol extracts showed significant reduction in inflammation at different 100, 200 and 500μg/ml compared to standard drug indomethacin (100μg/ml).

Conclusion: Based on the results, it can be concluded that the 80% ethanol extract of stem bark of Mesua ferrea Linn. (M. ferrea) exhibited significant anti-inflammatory activity compared to petroleum ether and chloroform extracts.

 


Keywords


Mesua ferrea Linn. Phytochemicals, Anti-inflammatory

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About this article

Title

EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY OF STEM BARK EXTRACTS OF MESUA FERREA LINN.

Keywords

Mesua ferrea Linn. Phytochemicals, Anti-inflammatory

Date

01-02-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 8, Issue 2, 2016 Page: 173-177

Online ISSN

0975-1491

Authors & Affiliations

Prathima Ranganathaiah
Kuvempu, University,
India

Manjunatha Hanumanthappa
Department of PG Studies and Research in Biotechnology and Bioinformatics, Kuvempu, University, Shankaraghatta 577451, Karnataka, India
India

Krishna Venkatarangaiah
Kuvempu, University,
India


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