@article{El-Dayem_Zaazaa_Foda_El-Aty_2016, title={QUERCETIN MITIGATES TOXICITY AND OXIDATIVE STRESS MOTIVATED BY BISPHENOL A IN LIVER OF MALE RATS}, volume={8}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/11927}, abstractNote={<p><strong>Objective: </strong>Epidemiological reports have indicated a correlation between the increasing of bisphenol A (BPA) levels in the environment and the incidence of hepatotoxicity. The present study aimed to evaluate the protective effect of <a href="http://www.sciencedirect.com/science/article/pii/S0944711304000121" target="_blank">quercetin</a> on oxidative stress, inflammatory markers, apoptotic and antiapoptotic markers in the liver tissue of the bisphenol A treated rats.</p><p><strong>Methods: </strong>Forty-eight male Wistar rats were divided into six groups; Group(1): Negative control group (Con), Group(2): Corn oil control group orally administered 1 ml of corn oil/rat daily for two months (Corn), Group(3): Olive oil control group orally administered 1 ml olive oil/rat daily for two months (Olive), Group(4): Quercetin (Qu) control group orally received Qu dissolved in olive oil (50 mg/kg b. wt.) daily for two months (Qu). Group(5): Positive control group orally received Bisphenol A (BPA) dissolved in corn oil in a dose of 50 mg/kg b. wt. daily for two months (BPA), Group(6): Quercetin treated group orally administered 50 mg/kg b. wt. of BPA and treated with Qu (50 mg/kg b. wt. Orally) daily for two months (BPA+Qu).</p><p><strong>Results: </strong>BPA exposure resulted in significant elevations of oxidative stress, as evidenced by the increased malondialdehyde level and glutathione-S-transferase activity associated with significant decrease in glutathione peroxidase activity in the liver tissue. Moreover, BPA caused an up regulation in the values of liver function enzymes. Also, BPA produced a significant elevation in the hepatic Interleuckin-6 (IL-6) and caspase-3 levels with a significant decline in antiapoptotic protein B-cell lymphoma 2 (Bcl2) level in liver tissue. Quercetin significantly attenuated the BPA-evoked liver oxidative stress and modulated the activities of liver function enzymes. In addition, treatment of quercetin with BPA resulted in an improvement of IL-6 and caspase-3 levels associated with a significant increase in hepatic protein Bcl2 expression.</p><p><strong>Conclusion: </strong>These data suggest that quercetin protects rat liver from BPA-induced oxidative stress, probably <em>via</em> its antioxidant activity, anti-inflammatory and antiapoptotic effects. So, <a href="http://www.sciencedirect.com/science/article/pii/S0944711304000121" target="_blank">Quercetin</a> is a promising pharmacological agent for preventing the potential hepatotoxicity of BPA following occupational or environmental exposures.</p><p><strong>Keywords: </strong>Bisphenol A<strong>, </strong>Quercetin<strong>, </strong>hepatotoxicity, Antioxidant, Anti-inflammatory<strong> </strong>effect,<strong> </strong>Antiapoptotic effect</p>}, number={7}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={El-Dayem, Samiha M. abd and Zaazaa, Asmaa M. and Foda, Fatma M. and El-Aty, Heba E. Abd}, year={2016}, month={Jul.}, pages={306–310} }