@article{Vikasari_Sukandar_Sutjiatmo_Riyanti_2015, title={DIURETIC EFFECT OF THE ETHANOL EXTRACTS OF PHYLLANTHUS ACIDUS L (SKEELS) LEAVES IN WISTAR RATS}, volume={7}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/3227}, abstractNote={<p><strong>Objective: </strong>The objective of this study is to test diuretic effect of ethanol extract of <em>P. acidus</em> leaves<em> </em>in female <em>Wistar</em> rats using modification of Lipschitz method.</p><p><strong>Methods: </strong>The doses of the extract were 22.5, 45 and 90 mg/kg bw. Parameter of diuretic effect was cumulative urine volume during 6 and 24 hours after administration of the extract. Sodium and potassium level in urine were analyzed using atomic absorption spectrophotometry (AAS). The results were analyzed with Student-t test.</p><p><strong>Results: </strong>The ethanol extracts of <em>P. acidus</em> at doses of 22.5, 45, and 90 mg/kg bw could accelerate the urinary in rats since 60 minutes after oral administration compared to the control and furosemide 3.6 mg/kg bw (P<0.05). The level of sodium on 24 hour urine of the ethanol extracts of <em>P. acidus</em> at doses 22.5 and 45 mg/kg bw significantly higher than control group (P<0.05), but significantly lower than furosemide 3.6 mg/kg bw (P<0.05). The level of potassium on 24 hour urine of the ethanol extracts of <em>P. acidus</em> at doses 45 and 90 mg/kg bw significantly higher than control group (P<0.05), but significantly lower than furosemide 3.6 mg/kg bw (P<0.05).</p><p><strong>Conclusion: </strong>It can be concluded that the ethanol extract of <em>P. acidus</em> at doses of 22.5 mg/kg bw, 45 mg/kg bw and 90 mg/kg bw had significantly diuretic and saluretic effect compared to control group (P<0.05), but significantly less than furosemid 3.6 mg/kg bw (P<0.05).</p>}, number={1}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={Vikasari, Suci Nar and Sukandar, Elin Yulinah and Sutjiatmo, Afifah Bambang and Riyanti, Soraya}, year={2015}, month={Jan.}, pages={120–123} }