@article{YAHYA_ABDULLAH_2020, title={SYNTHESIS OF SOME 2,3-DIHYDRO-1,3,4-OXADIAZOLES AND 4,5-DIHYDRO-1,2,4-TRIAZOLES AS ANTICANCER AGENTS}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/36508}, DOI={10.22159/ijpps.2020v12i8.36508}, abstractNote={<p><strong>Objective: </strong>The main objective of this work was to synthesize and evaluate the novel 2,3-dihydro-1,3,4-oxadiazole and 4,5-dihydro-1,2,4-triazole derivatives for cytotoxic activities.</p> <p><strong>Methods: </strong>The 2,3-dihydro-1,3,4-oxadiazole derivatives 4a-h were synthesized by cyclization of N’-(substituted-benzylidene) isonicotinohydrazide 3a-e in refluxing acetic anhydride. The 2,3-dihydro-1,3,4-oxadiazole derivatives 4a-h were converted into the corresponding 4,5-dihydro-1,2,4-triazoles 5a-h using ammonia. All the synthesized compounds were identified, depending on the physical and spectral data. Title compounds were assessed for their cytotoxic activity against human cancer cell line (MCF-7) by using Sulforhodamine B (SRB) colorimetric assay.</p> <p><strong>Results: </strong>All the synthesized compounds showed characteristic peaks in FTIR, <sup>1</sup>HNMR and Mass spectral analysis. The results of the <em>in vitro </em>cytotoxic activity revealed that the compound 4c exhibited equipotent cytotoxic activity with an IC<sub>50</sub> value of 8.04 µM when compared with that of standard drug doxorubicin (IC<sub>50</sub>= 8.02 µM). The reminder compounds have shown good to moderate cytotoxic activities when compared with that of a reference standard.</p> <p><strong>Conclusion: </strong>We synthesized a series of title compounds in quantitative yields. Most derivatives showed moderate to good cytotoxic activity.</p> <p> </p>}, number={8}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={YAHYA, TAWFEEK A. and ABDULLAH, JALAL H.}, year={2020}, month={Aug.}, pages={92–99} }