@article{VELLI_THIRUVENGADAM_2020, title={VANILLIC ACID INHIBITS LUNG CARCINOGENESIS BY MODULATES GLYCOPROTEIN ABNORMALITIES, MEMBRANE-BOUND ENZYMES, AND INFLAMMATORY MARKERS}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/36607}, DOI={10.22159/ijpps.2020v12i3.36607}, abstractNote={<p><strong>Objective: </strong>The current plan was accompanied to explicate the possible protective role of vanillic acid (VA), on modification in lipid peroxidation, inflammatory cytokines, membrane-bound enzymes, and glycoconjugates during B(a)P induced lung cancer in Swiss albino mice.</p> <p><strong>Methods: </strong>Benzo(a)pyrene was administered orally (50 mg/kg b. wt) to induce lung cancer in Swiss albino mice. lipid peroxidation, serum marker enzymes, inflammatory cytokines, membrane-bound ATPases and protein-bound carbohydrate components (Hexose, hexosamine, sialic acid and fucose) and Mast cells and PAS staining were carried out.</p> <p><strong>Results</strong>: Lung cancer possessing animals exhibited increased levels of lipid peroxidation, ADA, AHH, γ-GT, 5’-NT, LDH, cytokines such as TNF-α and IL-1β, protein-bound carbohydrate components (protein-hexose, hexosamine, sialic acid, and fucose) also diminished activity of membrane-bound ATPases (Na<sup>+</sup>/K<sup>+</sup>ATPases, Ca<sup>2+</sup>ATPases, and Mg<sup>2+</sup>ATPase). Treatment with VA significantly ameliorated all these activities.</p> <p><strong>Conclusion</strong>: Overall, the present study evidence to the VA has effective anti-inflammatory in addition to free radical scavenging activity for the duration of lung carcinogenesis in Swiss albino mice.</p>}, number={3}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={VELLI, SATHESH KANNA and THIRUVENGADAM, DEVAKI}, year={2020}, month={Mar.}, pages={83–88} }