@article{CHODANKAR_KUDCHADKAR_GUDE_NAVTI_SAWANT_2020, title={FORMULATION OPTIMIZATION AND EVALUATION OF FLURBIPROFEN EMULGEL}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/37330}, DOI={10.22159/ijpps.2020v12i8.37330}, abstractNote={<p><strong>Objective: </strong>The objective of the present study was to formulate flurbiprofen (FLB) emulgel, evaluation of the formulations and the selection of an optimized formulation through <em>in vitro </em>drug release and drug content studies. Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) requiring frequent administration and its chronic intake can lead to systemic side effects like gastric irritation and GI bleeding. The development of a dermal drug delivery system can overcome these side effects.</p> <p><strong>Methods: </strong>The emulgel formulations were produced using different combinations of oil and emulsifying agents. Carbopol 940 was used as a gelling agent. The prepared emulgels were evaluated for general appearance, pH, spreadability, extrudability, drug content, <em>in vitro</em> drug release, average globule size and viscosity.</p> <p><strong>Results: </strong>Optimized formulation F7 showed a better <em>in vitro</em> drug release compared to the marketed gel preparation. The stability study for the optimized formulation was carried out at 25 °C/60 % RH for 3 mo and the emulgel was found to be stable concerning the physical appearance, pH and drug content.</p> <p><strong>Conclusion: </strong>The study revolved around the formulation of emulgel containing Flurbiprofen for dermal delivery of the drug. Emulgel was formulated with the purpose to enhance the permeation of poorly water-soluble drug FLB. The study concluded that the optimized emulgel containing FLB exhibited better <em>in vitro</em> drug release profile compared to the marketed formulation.</p>}, number={8}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={CHODANKAR, DIKSHA S. and KUDCHADKAR, SACHI S. and GUDE, RAJASHREE S. and NAVTI, PRERANA D. and SAWANT, SANAM M.}, year={2020}, month={Aug.}, pages={49–54} }