@article{RAMDIKA_MAHATI_LEGOWO_MUNIROH_NINDITA_AFIFAH_2020, title={FORTIFIED DADIH (FERMENTED BUFFALO MILK) WITH VITAMIN D3 IMPROVES INTERLEUKIN-6 AND CAECUM SHORT CHAIN FATTY ACIDS ON DIET-INDUCED OBESE RAT}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/39209}, DOI={10.22159/ijpps.2020v12i11.39209}, abstractNote={<p><strong>Objective: </strong>This study aims to determine the effect of fortified dadih with vitamin D3 on IL-6 expression level and the concentration of caecum SCFA in obese rats.</p> <p><strong>Methods: </strong>A total of 30 male <em>Sprague Dawley</em> rats were divided into five equal groups: healthy-control-(K-), obese-control-(K+), obese-intervention-(X1, X2, and X3). K(+), X1, X2, and X3 were in obesity conditions, which was induced by a high-fat sucrose diet (HFSD) and K(-) as a healthy-control-group. Furthermore, vitamin D3-fortified dadih at doses of 4 g/200 g-body-weight/d, dadih only at doses of 4 g/200 g-body-weight/d, and vitamin D3 only at 36 IU/200 g-body-weight/d was administered to X1, X2, and X3 groups, respectively.</p> <p><strong>Results: </strong>Treatment using fortified dadih with vitamin D3 showed significantly reduce weight gain (p<0.05) compare to K(+) and X2. In addition, X1 showed a decreased level of Interleukin-6 expression (p<0.05) than K(+), X2, and X3 groups but higher than K(-). Also, it showed the highest total SCFA, acetate, and propionate concentration (p<0.05). However, a moderately negative correlation was discovered between the pair of total SCFA and Interleukin-6 expression, acetate and Interleukin-6 expression, SCFA and body weight, propionate and body weight, butyrate and body weight. On the contrary, a strong positive correlation was observed between the pair of Interleukin-6 expression levels and body weight.</p> <p><strong>Conclusion: </strong>This study shows that fortified dadih with vitamin D3 from fermented foods improve the expression level of Interleukin-6 and increase the production of SCFA. Also, they improve intestinal homeostasis because of the increased SCFA production.</p>}, number={11}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={RAMDIKA, SARI BEMA and MAHATI, ENDANG and LEGOWO, ANANG MOHAMAD and MUNIROH, MUFLIHATUL and NINDITA, YORA and AFIFAH, DIANA NUR}, year={2020}, month={Nov.}, pages={100–105} }