@article{Bandara_Karunaratne_Wickramasinghe_Wijesundara_Bandara_Karunaratne_2015, title={TOTAL POLYPHENOL CONTENT AND ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF THE SRI LANKAN ENDEMIC PLANT GENUS SCHUMACHERIA}, volume={7}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/4308}, abstractNote={<p><strong>Objective: </strong><em>Schumacheria</em>is a genus endemic to Sri Lanka distributed in lowland rain forests and mountain rain forests. The total polyphenol content and antioxidant and cytotoxic activities of hexane, dichloromethane and methanol extracts of stem-bark, root-bark, leaves and flowers of the three representative plant species<em>S. castaneifolia</em>, <em>S. alnifolia</em> and <em>S. angustifolia</em> belonging to the endemic genus <em>Schumacheria</em>are reported<em>. </em></p><p><strong>Methods: </strong>Antioxidant activity was determined using the DPPH (1,1-diphenyl-2-picrylhydrazine) radical scavenging assay. The total polyphenol content, expressed as the gallic acid equivalent, was determined using theFolin-Ciocaltue method and the cytotoxic activity was determined using the brine shrimp (<em>Artemiasalina</em>) assay.</p><p><strong>Results: </strong>The methanol extract of <em>S. castaneifolia</em> flowers (IC<sub>50</sub> = 6.8 ± 0.1 ppm)and the methanol extracts of <em>S. alnifolia</em> stem-bark (IC<sub>50</sub> =7.1 ± 0.4 ppm) and leaves (IC<sub>50</sub> =8.3 ± 0.3 ppm) showed antioxidant activity higher than that of α-tocopherol(IC<sub>50</sub> = 10.9 ± 4.3 ppm). The methanol extracts of <em>S. alnifolia</em> stem-bark (69.3 ± 6.9 mg g<sup>-1</sup>) and leaf (57.7 ± 0.0 mg g<sup>-1</sup>) extracts showed the highest polyphenol content closely followed by the methanol extracts of <em>S. castaneifolia</em> flowers (71.2 ± 0.6 mg g<sup>-1</sup>)<em>. </em>The highest cytotoxic activity was exhibited by the methanol extract of <em>S. castaneifolia</em> flowers (LC<sub>50 </sub>= 1.3 ± 0.7 ppm), and all the other extracts showed comparatively less cytotoxic activity.</p><p><strong>Conclusion: </strong><em>S. castaneifolia </em>and<em> S. alnifolia </em>exhibit potent bioactivitiesvalidating the ethnomedical claims where the former has been used for oral aphthous.</p><p> </p>}, number={3}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={Bandara, Chamara Janaka and Karunaratne, D Nedra and Wickramasinghe, Anura and Wijesundara, D. S. A and Bandara, B. M. Ratnayake and Karunaratne, Veranja}, year={2015}, month={Mar.}, pages={465–467} }