@article{Nouvlessounon_Sagbadja_Diarrassouba_Sina_NOUMAVO_Moussa_Adjanohoun_Gbenou_Moussa_2015, title={ANTIMICROBIAL, ANTIOXIDANT, CYTOTOXIC ACTIVITIES AND PHYTOCHEMICAL ASSESSMENT OF COLA ACUMINATA USED IN BENIN}, volume={7}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/5654}, abstractNote={<p><strong>Objective: </strong>The aim of this study was to make a phytochemical screening and measure some biological activities of <em>Cola acuminata’s</em> seeds and leaves extracts.</p><p><strong>Methods: </strong>The secondary metabolite was detected by the method based on coloring and precipitation differential reactions. The antibacterial and antifungal activities were assessed <em>in vitro</em> by the macrodillution and solid medium agar diffusion method. 2,2-diphényl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods were used to evaluate the antioxidant activity of the tested extracts of which larval cytotoxicity was studied.</p><p><strong>Results: </strong>Our data revealed that the seeds contain more polyphenols than the leaves. The seeds extracts displayed a good antibacterial activity against both reference strains and food <em>Staphylococcus</em> strains. The inhibition diameters varied from 7±2.82 to 21.5±4.94 mm. The smallest Minimum Inhibitory Concentrations<strong> </strong>(MIC) on the food strains (0.08 mg/ml) is twice less than the reference strains one (0.15 mg/ml), this observation is contrary to the Minimum Bactericidal concentrations (MBC). Susceptibility of fungal strains varies according to the extracts (p = 0.0016). The seeds ethyl acetate extracts had the best antioxidant activity with DPPH and ABTS methods. The Lethal Doses (LD<sub>50</sub>) showed that no extract was toxic.</p><p><strong>Conclusion: </strong><em>Cola</em><em> acuminata</em> seeds are richer than the leaves in compounds with biological activities. These two organs have interesting antimicrobial, antifungal and antioxidant activity variables depending to the extracts. The seeds have better biological activity than the leaves.</p><p> </p>}, number={6}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={Nouvlessounon, Durand Dah and Sagbadja, Hubert Adoukonou and Diarrassouba, Nafan and Sina, Haziz and NOUMAVO, PACOME A. and Moussa, Farid Baba and Adjanohoun, Adolphe and Gbenou, Joachim D. and Moussa, Lamine Baba}, year={2015}, month={Jun.}, pages={102–109} }