@article{Pednekar_Dandagi_Gadad_Mastiholimath_2015, title={FORMULATION AND CHARACTERISATION OF MELOXICAM LOADED EMULGEL FOR TOPICAL APPLICATION}, volume={7}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/7397}, abstractNote={<p><strong>Objective: </strong>The aim of the research work is to formulate emulgel of Meloxicam for topical application.</p><p><strong>Methods: </strong>The method used for preparation of microemulsion was water titration method with Oleic acid as oil phase, Tween 20 as surfactant and PEG 400 as co-surfactant and its concentrations were fixed based on Pseudoternary phase diagrams. The optimized emulsion formulation was incorporated into the gel matrix that is Carbopol981 NF and Carbopol 974 P NF.</p><p><strong>Results: </strong>The prepared emulsions were characterized for globule size, drug content, zeta potential and the emulgel for physical appearance, drug content, pH, viscosity, spreadability, extrudability and <em>in vitro </em>drug release studies. The optimized emulsion formulations E1 and F1 showed globule size of 176 nm and 128 nm respectively and the emulgel formulation M2F1 with 1.5% Carbopol 981 and optimized F1 emulsion formulation showed<em> in vitro</em> drug release of 89.934% at the end of 8 h. The optimized formulation showed no skin irritation when compared with standard irritant 0.8% of Formalin. The optimized formulation showed better anti-inflammatory effect when compared with marketed formulation.</p><p><strong>Conclusion: </strong>Meloxicam was proven to be a suitable candidate for formulating emulgel for topical delivery to achieve better patient compliance.</p><p> </p>}, number={11}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={Pednekar, Arti and Dandagi, Panchaxari and Gadad, Anand and Mastiholimath, Vinayak}, year={2015}, month={Nov.}, pages={216–222} }