@article{Dhianawaty_Panigoro_Martiana_Surialaga_Yulianti_Maliki_2016, title={POTENCY OF TURMERIC RHIZOME DECOCTION ON SPERM INFERTILITY OF MALE MICE TO SUCCEED FAMILY PLANNING PROGRAM IN WEST JAVA SOCIETY}, volume={8}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/9750}, abstractNote={<p><strong>Objective: </strong>The study aimed to evaluate the effect of turmeric<em> </em>rhizome decoction on sperm fertility of male mice.</p><p><strong>Methods: </strong>Ten male mice were divided randomly into two groups, control, and tested groups. The control and the tested groups were given water as vehicle and turmeric rhizome decoction at the dose 517.4 mg/kg body weight, respectively for 30 d. The mice were put under anesthesia by urethane, and the percentage of sperm motility, morphology, and sperm concentration were calculated, respectively. The results were compared with seminiferous tubule cell images.</p><p><strong>Results: </strong>The rapid progressive sperm motility of the control and the tested groups were 53±6.4 % and 13±3.6 %, respectively; the difference was significant (P<0.001). The normal sperm morphology in both the control and the tested groups were 57.8±5.76 % and 40.8±2.72 %, respectively; the difference was significant (P<0.01). However, the differences of sperm concentration of both groups were not considered significant. Seminiferous tubule cell images of the tested group showed disruption of sertoli cells along with the present of cellular vacuolization and pyknotic nuclei.</p><p><strong>Conclusion: </strong>Intake<strong> </strong>of the turmeric rhizome decoction at the dose of 517.4 mg/kg-bw in mice has a significant effect in decreasing the sperm motility and morphology. The decoction caused sperm abnormality or asthenoteratozoospermia. The habit of consuming turmeric decoction can succeed family planning program.</p><p><strong>Keywords</strong>:<strong> </strong>Asthenoteratozoospermia, Sperm infertility, <em>Curcuma longa </em>L., Turmeric, Decoction of turmeric rhizome</p>}, number={13}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={Dhianawaty, Diah and Panigoro, Ramdan and Martiana, Anna and Surialaga, Samsudin and Yulianti, Herry and Maliki, Adi Santosa}, year={2016}, month={Mar.}, pages={9–12} }