@article{Mishra_Phadnis_Vyas_Nyati_2016, title={STUDY OF CNS ACTIVITIES OF PIPERINE PERSE AND ITS BIOENHANCING EFFECT ON VARIOUS DRUGS IN EXPERIMENTAL ANIMAL MODELS}, volume={8}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/9978}, abstractNote={<p><strong>Objective: </strong>Study of CNS activities of piperine <em>perse</em> and its bio-enhancing effect on various drugs in experimental animal models.</p><p><strong>Methods: </strong>The CNS effects of piperine and its interaction with various drugs were evaluated by maximal electroshock convulsion model, pentobarbitone-induced sleeping time, anxiolytic activity, muscle relaxant activity and antidepressant activity using tail suspension and forced swimming test using standard procedures in experimental animal models. piperine at a dose of 10 and 20 mg/kg orally was used to evaluate CNS activities.</p><p><strong>Results: </strong>The results revealed that piperine <em>perse</em> posses only anticonvulsant activity and other significant CNS effects were not observe. But when it was combined with various drugs piperine increases the effect of the standard drug.</p><p><strong>Conclusion: </strong>Piperine 10 mg/kg has the potential to be used as a bio-enhancing agent when combined with other drugs. Bio-enhancing effect of piperine will decrease the dose of the standard drug, thereby decreasing the risk of their toxicity.</p><p><strong>Keywords: </strong>Piperine, Bio-enhancing, MES, Anxiolytic test, Tail suspension test, Forced swimming test, Motor co-ordination, Righting reflex</p>}, number={4}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={Mishra, Pooja Solanki and Phadnis, Pradeep and Vyas, Savita and Nyati, Prem}, year={2016}, month={Apr.}, pages={135–140} }