TY - JOUR AU - Gohel, Mukesh AU - Purohit, Ankita AU - Patel, Asha AU - Hingorani, Lal PY - 2016/12/01 Y2 - 2024/03/29 TI - OPTIMIZATION OF BACOSIDE A LOADED SNEDDS USING D-OPTIMAL MIXTURE DESIGN FOR ENHANCEMENT INSOLUBILITY AND BIOAVAILABILITY JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 8 IS - 12 SE - Original Article(s) DO - 10.22159/ijpps.2016v8i12.13488 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/13488 SP - 213-220 AB - <p><strong>Objective</strong>:<strong> </strong>The objective of present study is to enhance solubility and bioavailability of poorly soluble <em>bacoside A</em> present in <em>Bacopa monnieri</em> extract using self nano emulsifying drug delivery system (SNEDDS) for the treatment of Alzheimer's disease.</p><p><strong>Methods: </strong>Solubility of the drug was assessed in various oils (edible as well as synthetic oil), surfactant and co-surfactant by saturation solubility study. Pseudo-ternary phase diagram was used to obtain appropriate concentration ranges of components include oil, surfactant and co-surfactant.</p><p><strong>Results: </strong>From the result of saturated solubility study and phase diagram, oleic acid, tween 20 and ethanol was selected as oil, surfactant and co-surfactant. The D-Optimal mixture design was used to optimize the formulation on the basis of solubility of drug and dilution potential. <em>In vitro</em> dissolution, study showed 89% of drug release from optimized SNEDDS formulation compared to untreated drug<em> </em>extract with 24% of drug release in 60 min. Ex vivo diffusion study showed more than 90% of drug diffused from optimized SNEDDS formulation compared to pure extract.</p><p><strong>Conclusion: </strong>In a nutshell, the developed SNEDDS formulation using the design of experimentation approach held great potential as a possible alternative to traditional oral formulations of poorly soluble <em>Bacoside A </em>to improve solubility and bioavailability.</p> ER -