TY - JOUR AU - Sharma, Jagmoahan AU - Sharma, Shveta AU - Kaura, Arun AU - Durani, Sahil PY - 2014/10/01 Y2 - 2024/03/29 TI - FORMULATION AND IN-VITRO EVALUATION OF MOXIFLOXACIN OCULAR INSERTS JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 6 IS - 10 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/1606 SP - 177-179 AB - <p class="yiv3439916614msonormal"><strong>Objectives:</strong> Most ocular diseases are treated with topical applications of eye drops. After instillation of an eye drop, typically less than 5 % of the applied drug penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is absorbed and enters the systemic circulation. The objective of present work is to improve ocular bioavailability and corneal contact time of a Moxifloxacin for better permeation through cornea.</p><p class="yiv3439916614msonormal"><strong>Methods: </strong>Five formulations were prepared by film casting method. Polyvinyl pyrrolidene, methyl cellulose and hydroxyl propyl methyl cellulose were used as polymers. PEG 400 was used as plasticizer.</p><p class="yiv3439916614msonormal"><strong>Results:</strong> The release from the ocular inserts may be considered to follow zero order as evidenced from the regression coefficient (r2) value which is higher for MF4 (.9991).Â&nbsp; The release from formulation code MF1 was found to be 80 % upto 24 hrs. The release from formulations MF2 and MF3 was 91.7 % and 92.10 % respectively within 24 hrs. The release from formulation 4 was 95.23% within 24 hrs. The release from MF5 was upto 60.73% within 24 hrs. The ocular inserts of formulation MF5 were hard and brittle.</p><p class="yiv3439916614msonormal"><strong>Conclusion: </strong>The formulation MF4 has the potential to formulate moxifloxacin ocular inserts. However in-vivo studies in animals and antimicrobial studies are required before this could be evaluated as an alternative to moxifloxacin eye drops.</p> ER -