TY - JOUR AU - Salvador, Islaine De Souza AU - Silva Leite, Renata Da AU - De Souza, Valmir Gomes AU - De Andrade, Fabricio Havy Dantas AU - Batista, Rayanne Sales De A. AU - SOUZA, FABIO SANTOS DE AU - Macedo, Rui Oliveira PY - 2017/04/01 Y2 - 2024/03/29 TI - THE STUDY OF THE ACUTE AND SUB-ACUTE ORAL TOXICITIES OF THE NEBULIZED EXTRACT OF MYRACRODRUON URUNDEUVA ALLEMÃO IN RABBITS JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 9 IS - 4 SE - Original Article(s) DO - 10.22159/ijpps.2017v9i4.16743 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/16743 SP - 154-160 AB - <p><strong>Objective</strong>:<strong> </strong>The aim of this research was to evaluate the acute and sub-acute oral toxicities of the nebulized dried extract of<em> Myracrodruon urundeuva </em>(NDEMU) leaf obtained by the spray drying technique on rabbits.</p><p><strong>Methods</strong>:<strong> </strong>In the acute toxicity study, the amount of nebulized dried extract (NDE) administered was adjusted to a dose of 2000 mg/kg of leaf powder of <em>M. urundeuva</em> to 6 rabbits once orally and were observed for 14 days. In the sub-acute study, the amount of NDEMU administered was adjusted to a dose of 2000 mg/kg/day of to 6 rabbits once daily for 30 day, orally. The appearance of toxic symptoms was observed every day, followed by each rabbits' food and drink intake. Haematological and biochemical analysis were observed and statistical analysis was performed on them. The rabbits were killed at the end of the study, and their organs were weighed and examined before organ histology were evaluated.</p><p><strong>Results</strong>:<strong> </strong>No toxic signs and no mortality were observed in the acute and sub-acute study. In the sub-acute study, the amount of dried extract administered was adjusted to a dose of 2000 mg/kg of leaf powder of <em>M. urundeuva</em> to 6 rabbits once daily for 30 days, orally. No toxic signs and no mortality were observed. There were no significant changes (p &lt; 0.05) in the body weights, organ weights and haemato-biochemical parameters in any of the dose levels. No related histopathological lesions were observed.</p><p><strong>Conclusion</strong>:<strong> </strong>The results indicate that the treatment of repeated doses with the dried NDEME showed low toxicity in rabbits.</p> ER -