TY - JOUR AU - Yuvarani, Thanikasalam AU - Manjula, Kesavan AU - Gopu, Perumal Ananda PY - 2017/05/01 Y2 - 2024/03/29 TI - GROWTH CHARACTERIZATION OF CALCIUM HYDROGEN PHOSPHATE DIHYDRATE CRYSTALS INFLUENCED BY COSTUS IGNEUS AQUEOUS EXTRACT JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 9 IS - 5 SE - Original Article(s) DO - 10.22159/ijpps.2017v9i5.16838 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/16838 SP - 173-178 AB - <p><strong>Objective: </strong>To investigate the inhibitory effect of aqueous extract of leaves, stems and rhizome of <em>Costus igneus</em> on the growth of calcium hydrogen phosphate dihydrate (CHPD) crystals.</p><p><strong>Methods: </strong>Calcium hydrogen phosphate dihydrate (CHPD) crystals were grown by the single diffusion gel growth technique and the inhibitory effect of aqueous extracts of leaves, stems and rhizome of <em>Costus igneus</em> on the growth of CHPD crystals has been studied. The grown crystals were characterised by Fourier Transform Infrared Spectroscopy (FTIR), Powder X-Ray diffraction (XRD) for further confirmations.<strong></strong></p><p><strong>Results: </strong>With an increase in the concentration of aqueous extract of <em>Costus igneus</em>, the weight of the formed crystals were gradually reduced from 2.03 g to 0.06 g (leaves), 0.05 g (rhizome), 0.03 g (stem) for the CHPD crystals, respectively. The crystals harvested from the CHPD were characterised by Fourier Transform Infrared Spectroscopy (FTIR) to confirm the functional groups, and Powder X-Ray Diffraction technique (XRD) analyses to confirm the crystalline phases of the CHPD and hydroxyapatite (HAP) crystals. Results obtained indicated that <em>Costus igneus</em> (leaves, stems and rhizome) has the potential to inhibit the formation of calcium hydrogen phosphate dihydrate crystals.</p><p><strong>Conclusion: </strong>This study confirms that using an aqueous extract of stem and rhizome of <em>Costus igneus</em> can promote the formation of hydroxyapatite (HAP) crystals and reduce the nucleation rate of CHPD crystals, a major component of calcium urinary stone.</p> ER -