TY - JOUR AU - D., Manyasree AU - P., Kiranmayi AU - S. N., Ravi Kumar R. V. S. PY - 2018/01/01 Y2 - 2024/03/19 TI - SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF ALUMINIUM OXIDE NANOPARTICLES JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 10 IS - 1 SE - Original Article(s) DO - 10.22159/ijpps.2018v10i1.20636 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/20636 SP - 32-35 AB - <p><strong>Objective: </strong>In the present study, synthesized alumina (Al<sub>2</sub>O<sub>3)</sub> nanoparticles were characterized and their antibacterial activity against gram positive and gram negative organisms were studied.</p><p><strong>Methods: </strong>The synthesis was carried out by coprecipitation method using aluminium sulfate and NaOH as precursors. The synthesized aluminium oxide nanoparticles were characterized by using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR) and scanning electron microscope (SEM) with <em>Energy Dispersive X</em>-ray Analysis (EDX) techniques. Besides, this study determines the antibacterial activity and minimum inhibitory concentration (MIC) of Al<sub>2</sub>O<sub>3</sub> nanoparticles against gram-positive (<em>Staphylococcus aureus and Streptococcus mutans</em>) and gram-negative (<em>E. coli </em>and<em> Proteus vulgaris</em>) bacteria<em>. </em></p><p><strong>Results: </strong>The average crystallite size of Al<sub>2</sub>O<sub>3 </sub>nanoparticles was found to be 35 nm by X-ray diffraction. FT-IR spectrum exhibited the peaks at 615 and 636 were assigned to the aluminium oxide stretching. The EDX measurements indicated the presence of Al along with O peaks. It indicates the purity of the sample. The antimicrobial assay revealed that <em>E. coli</em> showed a maximum zone of inhibition (39 mm) at 50 mg/ml concentration of Al<sub>2</sub>O<sub>3 </sub>nanoparticles.</p><p><strong>Conclusion: </strong>In conclusion, aluminium oxide is a good antibacterial agent against both gram positive and gram-negative organisms.</p> ER -