TY - JOUR AU - Hardikar, Sharwaree AU - Bhosale, Ashok AU - Vanave, Swati AU - Kamathe, Bhagyashree PY - 2017/10/02 Y2 - 2024/03/29 TI - PREPARATION AND EVALUATION OF CO-CRYSTALS OF CARBAMAZEPINE WITH GLUCOMANNAN JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 9 IS - 10 SE - Short Communication(s) DO - 10.22159/ijpps.2017v9i10.20656 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/20656 SP - 318-320 AB - <p><strong>Objective: </strong>The objective of the present work was to inhibit transformation of carbamazepine anhydrous to its dihydrate form in aqueous medium by adopting the co-crystal approach.</p><p><strong>Methods: </strong>Co-crystallization of carbamazepine and glucomannan as co-former was carried out by solution mediated phase transformation. The solution of carbamazepine and glucomannan in ethanol (95%) was agitated for 2 h and the co-crystals obtained were recovered after 24 h.</p><p><strong>Results: </strong>Co-crystal formation due to hydrogen bonding between carbamazepine and glucomannan as a co-former was confirmed by FTIR study. Inhibition of transformation of co-crystal of carbamazepine to carbamazepine dihydrate in aqueous medium was confirmed by SEM.</p><p><strong>Conclusion: </strong>Inhibition of transformation of carbamazepine co-crystal to its dihydrate form resulted in its improved dissolution. Dissolution efficiency of carbamazepine in its co-crystal was increased up to 79.26% within 30 min.</p> ER -