TY - JOUR AU - ., Mahani AU - Sulaeman, A. AU - Anwar, F. AU - Damanik, M. R.m. AU - ., Hardinsyah AU - Ploeger, A. PY - 2018/04/01 Y2 - 2024/03/28 TI - DETERMINATION OF INDONESIAN NATIVE STINGLESS BEE PROPOLIS AS COMPLEMENTARY NUTRACEUTICAL CANDIDATE OF ANTI-TUBERCULOSIS DRUG JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 10 IS - 4 SE - Original Article(s) DO - 10.22159/ijpps.2018v10i4.23850 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/23850 SP - 15-21 AB - <p><strong>Objective: </strong>This study aimed to determine Indonesian native stingless bee propolis from ten provinces of Indonesia as complementary nutraceutical candidate of anti-tuberculosis drug (ATD).</p><p><strong>Methods: </strong>Propolis samples were collected from stingless bee cultivated in ten provinces of Indonesia. The antioxidant capacity test was performed using <em>2,2-diphenyl-1-picrylhydrazyl</em> and toxicity test was done using <em>Brine Shrimp Lethality Test</em>. The inhibition test of <em>M</em><em>ycobacterium tuberculosis</em> (<em>Mt</em><em>b</em>) was performed using <em>Lowenstein-J</em><em>e</em><em>nsen</em> medium and bacterial colonies were estimated using <em>Most Probable Number</em>.</p><p><strong>Results: </strong>The highest antioxidant capacity was found in <em>G</em><em>eniotrigona</em> <em>incisa</em><em> </em><em>(G. incisa) </em>propolis from South Sulawesi Province with an IC<sub>50</sub>of 100.05 ppm, while the lowest antioxidant capacity was found in <em>T</em><em>etragonula m</em><em>inangkabau</em><em> </em>propolis from North Sumatera Province with an IC<sub>50</sub> of 1378.90 ppm. The lowest propolis toxicity was found in <em>G</em><em>eniotrigona</em><em> </em><em>thorasica</em> propolis from South Kalimantan Province with an LC<sub>50</sub>of &gt;1000.00, while the highest propolis toxicity was found in <em>T</em><em>etragonula</em><em> </em><em>laeviceps</em> (<em>T. laeviceps</em>) propolis from Banten Province with an LC<sub>50</sub> of&lt;50.00. <em>T</em><em>. l</em><em>aeviceps</em> propolis from Banten Province had the lowest <em>Mtb</em> inhibition, with the inhibition value of 1.59%. On the other hand, the highest inhibition was shown by <em>T</em><em>etragonula </em><em>biroi</em> propolis from South Sulawesi Province and <em>T</em><em>etragonula f</em><em>uscobalteata</em> propolis from West Nusa Tenggara Province with 100% inhibition value (equivalent to <em>rifampicin</em>).</p><p><strong>Conclusion: </strong>Based on all determinant parameters, <em>G</em><em>. </em><em>incisa</em> propolis from South Sulawesi Province has the highest score, and it is defined as complementary nutraceutical candidate of ATD.</p> ER -