TY - JOUR AU - Naskar, Arup AU - Singha, Tanushree AU - Guria, Tanmoy AU - Singh, Jagadish AU - B, Ashok Kumar AU - Maity, Tapan Kumar PY - 2015/03/01 Y2 - 2024/03/29 TI - SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ANTICANCER ACTIVITY OF SOME NEW SCHIFF BASES OF 1, 3, 4-THIADIAZOLE DERIVATIVES JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 7 IS - 3 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/2538 SP - 397-402 AB - <p><strong>Objective: </strong>N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine derivatives: Synthesis and anticancer activity.<strong></strong></p><p><strong>Methods: </strong>In the present study five new derivatives of N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine (Schiff bases containing 1, 3, 4-thiadiazole) were synthesized according to the literature methods and were characterized by FT-IR, <sup>1</sup>H NMR spectroscopy and C, H, N analysis. Anticancer activity was evaluated in Male Swiss albino mice using Ehrlich's Ascites carcinoma cells. Compounds were administered at a dose of 25 mg/kg, body weight intraperitoneally.</p><p><strong>Results: </strong>The compounds were found to reduce tumor volume, viable cell count and increase the tumor weight (%) inhibition, ascites cells (%) inhibition, non-viable cell count and increase in life span (%ILS). All the compounds exhibited significant (P&lt; 0.01) anticancer activity compared to control and the compound 2d &amp; 4d was found to be most potent.</p><p><strong>Conclusion: </strong>It is concluded that synthesized Schiff bases of 2-amino-5-aryl-1, 3, 4-thiadiazoles derivatives are biologically active and developed into useful anticancer agents.</p><p> </p> ER -