TY - JOUR AU - M., Iyabo AU - ., Adebisi AU - Abubakar, Abba AU - Abubakar, Kabiru AU - R., Tijjani AU - ., Giaze PY - 2018/04/01 Y2 - 2024/03/29 TI - ANALGESIC EFFECT AND ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS EXTRACT OF BOSWELLIA DALZIELII (BURSERACEAE) STEM BARK JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 10 IS - 4 SE - Original Article(s) DO - 10.22159/ijpps.2018v10i4.26156 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/26156 SP - 139-142 AB - <h2>Objective: To evaluate the analgesic effect and anti-inflammatory properties of <em>Boswellia dalzielii </em>(Burseraceae), a medicinal plant commonly used in northern Nigeria as an anti-diarrhoeal, antipyretic, analgesic and anti-inflammatory agent.<em></em></h2><p><strong>Methods: </strong>Three doses (25 mg/kg, 50 mg/kg and 100 mg/kg) of the crude aqueous extract of <em>Boswellia dalzielii </em>were evaluated for analgesic and anti-inflammatory activities using the acetic acid-induced writhing test, formalin-induced nociception and formalin-induced hind paw oedema in rats. The acute oral toxicity was carried out using the up and down procedure as described by the OECD guidelines.<strong></strong></p><p><strong>Results: </strong>All doses (25, 50 and 100 mg/kg) of the extract tested were effective against acetic acid induced abdominal constrictions producing a percentage inhibition of (55.43, 69.56 and 71.73%) respectively. A percentage inhibition of the formalin-induced nociception of (7.31, 31.70 and 48.78%-early phase) and (12.82, 21.79 and 48.71%-late phase) respectively was also produced. For the acetic acid writhing test, the percentage inhibition obtained at the dose of 50 and 100 mg/kg (69.56 and 71.73%) were higher than that of the standard drug (Piroxicam, 10 mg/kg) (59.78%). For formalin-induced nociception, the test extract at 100 mg/kg showed a higher percentage inhibition compared to Piroxicam, in early (48.78 and 43.90%) and late phase (48.71 and 39.74 %) respectively. The extract, however, did not show a significant activity against formalin-induced paw oedema at all the doses used.</p><p><strong>Conclusion: </strong>The present study demonstrated that <em>Boswellia dalzielii </em>has significant analgesic properties comparable to that of the standard drug (10% Piroxicam), thus validating the traditional claim of its antinociceptive property.</p> ER -