TY - JOUR AU - ABDELAZIZ, MAHMOUD N. AU - ZARIE, EMAN S. AU - SARHAN, ALAADIN E. PY - 2020/03/01 Y2 - 2024/03/29 TI - SYNTHESIS AND UTILITY OF NEW POLYCYCLIC COMPOUNDS AS POTENTIAL ANTIMICROBIALS BASED ON CHROMENE MOIETY JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 12 IS - 3 SE - Erratum DO - 10.22159/ijpps.2019v11i9.34338 UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/37294 SP - 100 AB - <p><strong>Objective: </strong>The present research aims to synthesize some new polycyclic compounds including chromene moiety and study their antimicrobial activity.</p><p><strong>Methods: </strong>Several new polycyclic systems including chromene scaffold incorporated with pyridine, pyrimidine, imidazopyrimidine, and imidazodiazocine were achieved <em>via </em>condensation reaction of chromene derivative under the proper condition with various reagents namely; cyanothioacetamide, phenyl isothiocyanate, malononitrile, carbon disulfide, benzaldehyde, triethyl orthoformate, and 1,4-dichlorobutane. Moreover, a chlorodiazenyl chromene derivative was reacted with some substances possessing active–CH<sub>2</sub>-bridge such as ethyl cyanoacetate and malononitrile to end up with hydrazono compounds. Such compounds were eventually cyclized with hydrazine hydrate to form pyrazole and oxopyrazole derivatives. Moreover, compound 1 was treated with benzoyl acetone, and then followed by cyclization with malononitrile to provide the corresponding 2-amino14-(4-methoxyphenyl)-4-methy-5-phenyl-14H-benzo[5,6] chromeno [2,3H][1,6]naphthyridine-3-carbonitrile (20).</p><p><strong>Results: </strong>The results of the antimicrobial screening <em>in vitro</em> revealed that the inhibition zone (mm) of the synthesized compounds 1-3, 5 and 8 implied their optimum antibacterial activity, while the compounds 4, 6 and 9-13, 15 showed a moderate to weak antibacterial activity against multiple species of <em>B. subtilis, S. aureus, E. coli and P. aeruginosa</em>. In contrast, the compounds 1, 6, 11, 15 showed high antifungal activities against different species of <em>A. flavinand C. albicans</em>, while the other compounds exhibit a moderate to poor antifungal activity.</p><p><strong>Conclusion: </strong>It is remarkable that a series of chromene derivatives synthesized by a simple and available method leads to a molecule of promising antimicrobial activity. Further research is recommended to approve the importance of polycyclic systems for various applications.</p> ER -