TY - JOUR AU - Mir, Raouf Ahmad AU - Kaushik, Pradeep Suresh AU - Chowdery, Rukaya Amin AU - M, Anuradha PY - 2015/10/01 Y2 - 2024/03/29 TI - ELICITATION OF FORSKOLIN IN CULTURES OF RHIZACTONIA BATATICOLA-A PHYTOCHEMICAL SYNTHESIZING ENDOPHYTIC FUNGI JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 7 IS - 11 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/7318 SP - 185-189 AB - <p><strong>Objective: </strong><em>Coleus forskohlii </em>is the only known source of forskolin-a labdanediterpene and a highly valuable phytochemical. <em>Coleus forskohlii </em>has been listed as endangered plant; therefore, efforts have been made to find novel sources of forskolin production.<strong></strong></p><p><strong>Methods: </strong>Endophytic fungi were isolated from <em>Coleus forskohlii</em> tissue and screened for forskolin production by using thin layer chromatography (TLC) method. Further, 16 different elicitation media combinations were used to enhance the forskolin content.<strong></strong></p><p><strong>Results: </strong>In this study, out of 38 strains of endophytic fungi from <em>Coleus forskohlii </em>only 2 strains EF1 and EF2 were found to synthesize forskolin in mycelium, whereas EF2 was found to release the forskolin into the broth. Further, EF2 was identified as <em>Rhizactonia bataticola</em> accession no. NFCCI 2028. Further, T<sub>2</sub>S<sub>1 </sub>media showed dramatic effects on enhanced forskolin production in mycelium. However, there was a significant increase about four folds in broth which corresponded to 0.5 mg compared to T<sub>1</sub>S<sub>1</sub> media where it was 0.09 mg.<strong></strong></p><p><strong>Conclusion: </strong>The present study suggests that the forskolin producing <em>Rhizactonia bataticola </em>and T<sub>2</sub>S<sub>1 </sub>media can serve as potential materials for large scale enhancement of forskolin production. <strong></strong></p><p> </p> ER -