TY - JOUR AU - Sukandar, Elin Yulinah AU - Kurniati, Neng Fisheri AU - Anggadiredja, Kusnandar AU - Kamil, Annisa PY - 2016/01/01 Y2 - 2024/03/28 TI - IN VITRO ANTIBACTERIAL ACTIVITY OF KAEMPFERIA PANDURATA ROXB. AND CURCUMA XANTHORRHIZA ROXB. EXTRACTS IN COMBINATION WITH CERTAIN ANTIBIOTICS AGAINST MSSA AND MRSA JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 8 IS - 1 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/8912 SP - 108-111 AB - <p><strong>Objective: </strong>The aim of this study was to find an alternative treatment of MRSA infection. We evaluated the interaction of <em>in vitro</em> antibacterial activity of <em>Kaempferia pandurata</em> Roxb. (rhizome) or <em>Curcuma xanthorrhiza</em> Roxb. (rhizome) ethanolic extracts combined with commonly used antibiotics, namely penicillin V, ampicillin, ciprofloxacin HCl, and tetracycline HCl.</p><p><strong>Methods: </strong>Interaction between the plant extracts and antibiotics against <em>Methicillin-sensitive Staphylococcus aureus</em> (MSSA) and <em>Methicillin-resistant Staphylococcus aureus</em> (MRSA) were tested by checkerboard method and interpreted as Fractional Inhibitory Concentration (FIC) index.</p><p><strong>Results: </strong><em>Kaempferia pandurata</em><em> </em>showed a synergistic effect on all antibiotics tested against MSSA. Against MRSA, however, only combinations of <em>Kaempferia pandurata</em><em> </em>and penicillin V or ampicillin which showed synergism, while others were antagonisms. Meanwhile, with <em>Curcuma xanthorrhiza</em>, only its combination with ampicillin which resulted in synergistic effect against both MSSA and MRSA, others resulted in various interaction responses against MSSA and MRSA.</p><p><strong>Conclusion: </strong>Interaction between <em>Kaempferia pandurata</em> and penicillin V or ampicillin and that between <em>Curcuma xanthorrhiza</em> and<em> </em>ampicillin resulted in synergistic effect against MRSA. These combinations are promising to be developed as an alternative strategy to treat MRSA.</p><p> </p> ER -