TY - JOUR AU - Mishra, Pooja Solanki AU - Phadnis, Pradeep AU - Vyas, Savita AU - Nyati, Prem PY - 2016/04/01 Y2 - 2024/03/28 TI - STUDY OF CNS ACTIVITIES OF PIPERINE PERSE AND ITS BIOENHANCING EFFECT ON VARIOUS DRUGS IN EXPERIMENTAL ANIMAL MODELS JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 8 IS - 4 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/9978 SP - 135-140 AB - <p><strong>Objective: </strong>Study of CNS activities of piperine <em>perse</em> and its bio-enhancing effect on various drugs in experimental animal models.</p><p><strong>Methods: </strong>The CNS effects of piperine and its interaction with various drugs were evaluated by maximal electroshock convulsion model, pentobarbitone-induced sleeping time, anxiolytic activity, muscle relaxant activity and antidepressant activity using tail suspension and forced swimming test using standard procedures in experimental animal models. piperine at a dose of 10 and 20 mg/kg orally was used to evaluate CNS activities.</p><p><strong>Results: </strong>The results revealed that piperine <em>perse</em> posses only anticonvulsant activity and other significant CNS effects were not observe. But when it was combined with various drugs piperine increases the effect of the standard drug.</p><p><strong>Conclusion: </strong>Piperine 10 mg/kg has the potential to be used as a bio-enhancing agent when combined with other drugs. Bio-enhancing effect of piperine will decrease the dose of the standard drug, thereby decreasing the risk of their toxicity.</p><p><strong>Keywords: </strong>Piperine, Bio-enhancing, MES, Anxiolytic test, Tail suspension test, Forced swimming test, Motor co-ordination, Righting reflex</p> ER -