International Journal of Pharmacy and Pharmaceutical Sciences
https://journals.innovareacademics.in/index.php/ijpps
<div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div>Innovare Academic Sciences Pvt Ltden-USInternational Journal of Pharmacy and Pharmaceutical Sciences2656-0097A REVIEW ON TEMPLATE SYNTHESIS OF NANOPARTICLE
https://journals.innovareacademics.in/index.php/ijpps/article/view/50661
<p>In recent years, there has been a rise in interest in the development of novel drug delivery systems that utilize nanoparticles. In terms of high stability, high specificity, high drug-carrying capacity, controlled release, the ability to use different routes of administration, and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles can offer significant advantages over conventional drug delivery. We try to provide a detailed overview of template techniques designed for nanomaterial production. The pores and channels in the nanoporous “template” structures are used to generate the desired nanomaterials in template synthesis. Because this process has advantages over other methods, like allowing precise control over their size, shape, and structure, it is commonly used to generate nanoparticles. The first half of the review provides information on various template preparation processes. Templates are classified as “hard” or “soft” templates. Soft templates are often fluid-like, whereas hard templates are typically solid-state materials with distinct morphology and structure. This study discusses the effect of templates on morphologies, and methodology, and compares hard and soft templates.</p>SAKSHI GHARATAISHWARYA GHADGESWAPNIL D. PHALAKVISHAL BODKEADITI GAVANDDARSHANA GANVIRDEEPTI GAIKWAD
Copyright (c) 2024 SAKSHI GHARAT, AISHWARYA GHADGE, SWAPNIL D. PHALAK, VISHAL BODKE, ADITI GAVAND, DARSHANA GANVIR, DEEPTI GAIKWAD
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2024-03-262024-03-2610.22159/ijpps.2024v16i5.50661PREPARATION AND CHARACTERIZATION OF FLUCONAZOLE TOPICAL NANOSPONGE HYDROGEL
https://journals.innovareacademics.in/index.php/ijpps/article/view/50589
<p><strong>Objective</strong>: The study aimed to develop a polymeric nanosponge-based hydrogel system for enhanced topical application of fluconazole, an antifungal drug.</p> <p><strong>Methods</strong>: Nanosponges were formulated using the emulsion solvent diffusion method using various polymers like hydroxypropyl methylcellulose, ethylcellulose and Eudragit RS 100. Polyvinyl alcohol and ethanol were used to prepare the aqueous and dispersed phases. Nanosponges were dispersed in appropriate amount of gelling agent Carbopol 940 to get nanosponge gel. Drug–polymer interaction has been carried out by FTIR spectroscopy. The prepared nanosponges were evaluated for various tests like production yield, drug entrapment efficiency, compatibility and SEM studies. The nanosponge hydrogel was tested for pH, drug content, spreadability, in-vitro diffusion and kinetic studies.</p> <p><strong>Results</strong>: The drug entrapment efficiency of fluconazole nanosponges was found in the range of 52.3 ± 0.84% to 80.8 ± 0.36% for all formulations respectively. The spreadability of prepared nanosponges gel formulation was in the range between 5.20±0.19 to 7.187±0.85.</p> <p>Particle size analysis showed that the average particle size of fluconazole nanosponges formulated using ethyl cellulose (F5) was found to be 334 nm. The zeta potential was found to be -10.4 mV indicating the formulated fluconazole nanosponges (F5) had moderate stability. FTIR and DSC studies of pure drug and nanosponges suggested that the formulations were stable and there was no chemical interaction with polymer and other excipients. The optimised fluconazole topical nanosponge hydrogel (FG5) released 90.90% drug in 8 h.</p> <p><strong>Conclusion</strong>: Fluconazole topical nanosponge hydrogel could be successfully prepared by emulsion solvent diffusion method. Fluconazole topical nanosponge hydrogel showed promising results under in-vitro condition and thus there exists a scope for evaluation of the developed nanosponge hydrogel for further pharmacokinetic studies, using appropriate test models.</p>SARFARAZ MDSHAIKH ZAMIRULLAH MEHBOOBH. DODDAYYA
Copyright (c) 2024 SARFARAZ MD, SHAIKH ZAMIRULLAH MEHBOOB, H. DODDAYYA
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2024-03-012024-03-0110.22159/ijpps.2024v16i4.50589EXPLORING THE THERAPEUTIC POTENTIAL OF LOW-DOSE COLCHICINE IN CORONARY ARTERY DISEASE: AN IN-DEPTH ANALYSIS OF INFLAMMATION, SAFETY, AND CLINICAL EFFECTIVENESS
https://journals.innovareacademics.in/index.php/ijpps/article/view/50574
<p>Coronary Artery Disease (CAD) is a prevalent cardiovascular illness that is a primary cause of morbidity and mortality globally. It is distinguished by the constriction or blockage of the coronary arteries, which limits blood circulation to the heart. Inflammation is a driving force in the pathophysiology of CAD. Colchicine is an anti-inflammatory medication that has lately been studied for its potential application in the treatment of CAD. Its multimodal method of action has sparked interest due to its ability to treat inflammation and lower the concentration of critical inflammatory biomarkers. Clinical evidence validates the safe and effective use of Colchicine in CAD. Several recommendations advocate the use of Colchicine in the secondary prevention of CAD. This article discusses the use of low-dose colchicine in CAD, its function in inflammation, as well as its safety and therapeutic effectiveness.</p>VARSHITHA SRINIVASSWATHY SURESH
Copyright (c) 2024 VARSHITHA SRINIVAS, SWATHY SURESH
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2024-03-262024-03-2610.22159/ijpps.2024v16i5.50574