International Journal of Pharmacy and Pharmaceutical Sciences <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> Innovare Academic Sciences Pvt Ltd en-US International Journal of Pharmacy and Pharmaceutical Sciences 2656-0097 CASE SERIES OF EMERGING NOSOCOMIAL MULTIPLE DRUG RESISTANT PATHOGEN PROVIDENCIA RETTGERI CAUSING URINARY TRACT INFECTION <p>We report Case Series of Emerging Nosocomial Multiple Drug Resistant Pathogen <em>Providencia rettgeri </em>causing Urinary Tract Infections. The most common cause of catheter associated urinary tract infections (CAUTI), especially with long-term indwelling urinary catheters in elders, are <em>P.rettgeri</em> and <em>P.stuartii</em>. We are reporting 4 cases of UTI, which are hospital-acquired and CAUTI. These cases are admitted to MICU for treatment purposes and later develop fever spikes after a few days and are evaluated and urine culture showed multi-drug-resistant <em>Providencia rettgeri</em> by VITEK. The empirical therapy was discontinued, managed with fosfomycin, and discharged later with follow-up. The various reports showed <em>P.rettgeri</em>is susceptible for amikacin, gentamicin, tobramycin and ciprofloxacin. In our case series, we isolated multi-drug-resistant strains of <em>P.rettgeri</em> showed resistance to piperacillin-tazobactam, cefuroxime, ceftriaxone, cefepime, ertapenem, imipenem, meropenem, gentamicin, tobramycin, ciprofloxacin, tigecycline, amikacin, colistin and sensitive only to fosfomycin. The significance of <em>P.rettgeri</em> in association with catheter-related bloodstream infections (CRBSI) and catheter-associated urinary tract infections (CAUTI) was unclear. Hence isolation of Providencia species twice from the clinical samples was considered for association with catheter infections. The proper selection of empirical antimicrobials, antibiotic sensitivity testing, avoiding misuse of antibiotics and implementing proper drug holiday and local antibiotic policy are considered appropriate combination protocol for managing emerging multi-drug-resistant nosocomial <em>Providencia rettgeri</em> strains.</p> MAYURI MAHAJAN PRASANNA S. NIKUNJA KUMAR DAS NIKHIL MAHAJAN Copyright (c) 2022 MAYURI MAHAJAN, PRASANNA S., NIKUNJA KUMAR DAS, NIKHIL MAHAJAN 2022-12-05 2022-12-05 10.22159/ijpps.2023v15i1.46740 BOMBAX CEIBA LINN: A CRITICAL REVIEW ON PHYTOCHEMISTRY, TRADITIONAL USES, PHARMACOLOGY, AND TOXICITY FROM PHYTOPHARMACEUTICAL PERSPECTIVE <p>Traditional medicines are becoming crucial and decisive role in the prevention and cure of diseases and disorder. Traditional medicines have various pharmacological activities which important for human health. <em>Bombax Ceiba</em> widely used from past decades for treatment of diseases and disorders. <em>Bombax ceiba</em> is usually referred to as kapok tree and moca which belongs to <em>Bombacaceae</em>. Moca is a crucial medicative, plant widely found in tropical and subtropical Asian country like India, Pakistan. Various scientific studies or medicative usage has been reported within the traditional systems of drugs like Ayurveda, Siddha and Unani. Owing to this widespread attention about traditional medicines scientific validations of medicinal plants have become a thrust area of research. In this paper the scientific validation of <em>Bombax ceiba</em> for various biological activities has been reviewed with its chemical constituents present in whole plant and with its traditional and contemporary uses. This manuscript also provide deep inside of recent patents associated with <em>Bombax ceiba</em> in past decade.</p> NIRAJ GUPTA DEVENDER SHARMA REKHA RANI Copyright (c) 2022 NIRAJ GUPTA, DEVENDER SHARMA, REKHA RANI 2022-12-05 2022-12-05 10.22159/ijpps.2023v15i1.46533 LEFLUNOMIDE TABLET FORMULATION: DEVELOPMENT AND VALIDATION OF AN RP-HPLC TECHNIQUE <p><strong>Objective:</strong> To develop a Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method for Leflunomide using rapid, cheap economical, and less composition of the mobile phase. To validate the method's specificity, linearity, precision, accuracy, robustness, and ruggedness were all validated as per regulatory requirements ICH Q<sub>2 </sub>[R1] guidelines<strong>.</strong></p> <p><strong>Methods:</strong> The method employed solving of Development and validation based on the measurement of absorbance at one wavelength, 251nm, λ max, Inertsil -ODS C18 analytical column (250 x 4.6 mm, 5μ ). 1.0 ml/min of a mobile phase consisting of water and methanol (40:60v/v) for Leflunomide tablet formulation.</p> <p><strong>Results:</strong> The method showed excellent linear response with correlation coefficient (<em>R</em><sup>2</sup>) values of 0.999 for a Leflunomide. The percent recoveries for a drug were found within the acceptance limit of (99.93%–100.34%). Intra-and inter-day precision studies of the new method were less than the maximum allowable limit percentage of relative standard deviation (%RSD) ≤ 2.0. It can be concluded from the results that the present method for validation determination of Leflunomide in tablets is specific, rapid, and simple with good sensitivity.</p> <p><strong>Conclusion:</strong> This analytical method is also applicable in ordinary laboratories and also technique may be used to measure the drug and assess the uniformity and purity of the dosage formulation as well as for quality control of commercial Leflunomide tablets.</p> POTHURAJU NARESH K. VINOD KUMAR Copyright (c) 2022 POTHURAJU NARESH, K. VINOD KUMAR 2022-12-05 2022-12-05 10.22159/ijpps.2023v15i1.46505