International Journal of Pharmacy and Pharmaceutical Sciences <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> Innovare Academic Sciences Pvt Ltd en-US International Journal of Pharmacy and Pharmaceutical Sciences 2656-0097 COMPREHENSIVE MOLECULAR STUDY REVEALS THE POTENTIAL ROLE OF CHEBULINIC ACID AND BOERAVINONE B TO ESTABLISH REDOX HOMEOSTASIS IN METABOLICALLY STRESSED CELLS <p><strong>Objective:</strong> Our objective was to assess the multi-dimensional protective mechanism of Chebulinic acid (CA) and Boeravinone B (BB) against MG-induced metabolic stress and cytotoxicity.</p> <p><strong>Methods: </strong>In this study, we have studied CA- and BB-mediated changes in molecular markers of highly dynamic mechanisms of mitochondrial disintegration, nuclear damage and cell death pathways associated with early ageing in MG-exposed <em>Saccharomyces</em> <em>cerevisiae </em>cells using biochemical assays, qRT-PCR and flow cytometry.</p> <p><strong>Results:</strong> We found that CA and BB interventions during MG-induced stress in <em>S. cerevisiae</em> reduce the rate of extracellular nitrite production, protein carbonyl content, lipid peroxidation and in addition phytocomponents positively modulate the expression patterns of genes involved in different cell death pathways. Furthermore, CA and BB treatments to MG-stressed cells reduced the number of cells in late apoptosis by 13.4% and 28.3%, respectively. On top of that, CA and BB supplementation during MG-stress restored mitochondrial membrane potential (ΔΨm) by 63.0% and 62.5%, respectively.</p> <p><strong>Conclusion:</strong> Based on the results of this study, it seems CA and BB phytotherapy protect against MG-induced cytotoxicity through their natural antioxidant properties by establishing redox homeostasis; thus, CA and BB defend the cell components from oxidative damage of different biomolecules and organelles, ultimately increase longevity.</p> HARSHAD K. BOTE SAMIDHA S. KAKADE SHIVTEJ P. BIRADAR RAHUL V. KHANDARE PANKAJ K. PAWAR Copyright (c) 2022 Harshad Bote, Samidha Kakade, Shivtej Biradar, Rahul Khandare, Pankaj K. Pawar 2022-05-31 2022-05-31 10.22159/ijpps.2022v14i7.45042 MOLECULAR DOCKING AND COMPUTATIONAL PHARMACOKINETIC STUDY OF SOME NOVEL COUMARIN – BENZOTHIAZOLE SCHIFF’S BASE FOR ANTIMICROBIAL ACTIVITY <p><strong>Objective: </strong>The present study discusses molecular docking of some novel coumarin – benzothiazole Schiff bases and the prediction of pharmacokinetic properties of potent molecules by the computational method.</p> <p><strong>Methods: </strong>Five protein targets were selected for the study and their structures were taken from RCSB Protein Data Bank in PDB format. Preparation of proteins was done using Discovery Studio 2021 Client. A total of twenty derivatives were drawn using ChemDraw 20.0 and saved in Mol format. Molecular docking was performed using PyRx software. Docking results were visualized by Discovery Studio 2021 Client. The pharmacokinetic properties of the best compounds were determined using the pkCSM tool.</p> <p><strong>Results: </strong>All twenty derivatives were docked against the five proteins namely DNA Ligase (PDB ID: 3PN1), Topoisomerase (PDB ID: 3TTZ), Sterol demethylase (PDB ID: 5FSA), Enoyl-acyl-carrier protein (PDB ID: 1BVR) and Glutamate racemase (PDB ID: 5HJ7). The compound JJB18 has shown the best binding score against DNA ligase (-10.7 kcal/mol), Glutamate racemase (-8.4 kcal/mol), and Enoyl-acyl-carrier protein (-10.8 kcal/mol). Further, compound JJB19 has shown the best score for fungal sterol demethylase (-10.6 kcal/mol) and compound JJB20 towards topoisomerase (-9.4 kcal/mol) than the standard drugs. The physicochemical properties of potent derivatives were also reported.</p> <p><strong>Conclusion: </strong>Molecular Docking study indicates that coumarin – benzothiazole Schiff bases may be effective inhibitors for the different microbial proteins. Additionally, <em>in silico </em>ADMET studies predicts drug-like features. Hence, these compounds may be considered lead molecules and further investigation of their analogues may help in the development of novel drugs for the treatment of microbial diseases.</p> BURHANUDDIN MADRIWALA JUDY JAYS G. CHAITANYA SAI Copyright (c) 2022 Burhanuddin Madriwala Burhanuddin Madriwala 2022-06-21 2022-06-21 10.22159/ijpps.2022v14i8.45046 INFLUENCE OF PARTIALLY AND FULLY PREGELATINIZED STARCH ON THE PHYSICAL AND SUSTAINED-RELEASE PROPERTIES OF HPMC-BASED KETOPROFEN ORAL MATRICES <p><strong>Objective:</strong> This study aims to investigate the effect of two types of pregelatinized starch on the physical performance of HPMC matrices containing Ketoprofen as a model drug.</p> <p><strong>Methods:</strong> The design of the experiment was inspired by the monothetic analysis, in which testing factors or causes is done one factor or cause at a time, to achieve system improvements. Tablets were prepared by direct compression. The impact of the type of modified starch on the tablet's physicochemical properties was studied by testing for weight variation, friability, hardness, and drug release properties. PCP dissolution software was used to investigate the kinetics of drug release from matrix tablet formulation.</p> <p><strong>Results:</strong> The impact of the type of modified starch on tablet physicochemical attributes revealed that the weight variation of tablets was affected by the amount of modified starch used and that the combination of 64.7% partially pregelatinized starch (Starch<sup>Ò</sup> 1500) with 9.5% HPMC (F8) was found to be the better in terms of weight variation (%RSD= 1.73%) when compared with those containing fully pregelatinized starch (LYCATAB<sup>Ò</sup>). All formulation runs have friability that complies with pharmacopeial limits of less than 1% loss upon test conduction except for (F1). Formulations containing LYCATAB<sup>Ò</sup> showed better friability than those containing Starch<sup>Ò</sup> 1500, and similar results were observed in tablet hardness as well, in which the formulation containing the highest LYCATAB<sup>Ò</sup> concentration showed a significant increase in mechanical strength (P = 0.0004) than those containing the highest concentration of Starch<sup>Ò</sup> 1500. Finally, all formulations containing LYCATAB<sup>Ò</sup> exhibited sustained-release behavior, less than 60% of the drug was released from matrices over 14 h, and it is believed that the drug is transported via Fickian diffusion and followed either Higuchi or Peppas model (n &gt; 0.5), while all formulations containing Starch<sup>Ò</sup> 1500 released ~90% of the drug around 2 h, this might probably be due to the high disintegration effect of the partially pregelatinized starch, which is lost upon full pregelatinization.</p> <p><strong>Conclusion:</strong> Tablet weight variation, hardness, friability, and T<sub>50%</sub> were found to be influenced by both the type and concentration of modified starch used. While drug release characteristics were greatly affected by the type of modified starch used. For sustain-release formulations, only fully pregelatinized starch is thought to be suitable.</p> WALEED ELBALLA MOHAMMED SALIH Copyright (c) 2022 Waleed Elballa, Mohammed Salih 2022-06-21 2022-06-21 10.22159/ijpps.2022v14i8.45031