International Journal of Pharmacy and Pharmaceutical Sciences <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> Innovare Academic Sciences Pvt Ltd en-US International Journal of Pharmacy and Pharmaceutical Sciences 2656-0097 TRENDS IN PRESCRIPTION PATTERN IN MEDICAL INDIAN ICU AND IT’S IMPACT ON PATIENT OUTCOME <p><strong>Objective: </strong>The objective of this study is to evaluate the trends in prescribing pattern in medical ICU concerning patient age, gender, past, and current illness along with comorbidities for the evasion of polypharmacy and to improve patient outcomes.</p> <p><strong>Methods:</strong> A prospective analysis of the case records of patients admitted to the ICU of Yashoda hospital in India was carried out. </p> <p><strong>Results:</strong> 120 patients were evaluated consisting of 77% male patients. The Mean ± SD of age is 53.81±14.63. The majority of the study subjects belonged to the age group of 50-67 years (32%) Most common causes for admission to the ICU were Respiratory diseases and Stroke. Diabetes mellitus and Hypertension are the most common co-morbidities identified. The total number of drugs used were 1502 during this study period. The average number of drugs per prescription is 12. The range is between 2-30. The average number of antibiotics per prescription is 3. Commonly prescribed drug classes were the GI agents in 100% of patients, followed by antimicrobial agents (AMAs) in 95.8% of patients. About 42.5% of patients received 3 antibiotics per day. 55 potential drug-drug interactions were interpreted in 46 patients. 30(55%) were moderate interactions 25(45%) were major interactions, which were addressed. De-escalation of antibiotics was seen in 29% of patients while escalation in 13%. The death rate is only 5% in our ICU setting.</p> <p><strong>Conclusion:</strong> This prescription pattern study can provide a framework for continuous prescription audit in the ICU</p> VENKAT RAMAN KOLA MEDA HEMASREE SHARON ROSE KISHORE Copyright (c) 2021 Dr. Venkat Raman Kola, Hemasree Meda, Sharon Rose, Kishore 2021-12-01 2021-12-01 10.22159/ijpps.2022v14i1.43387 ROLE OF BIOMARKERS IN EPILEPTOGENESIS: A CONCISE REVIEW <p>Epilepsy is a gathering of ongoing neurological problems described by intermittent, unconstrained, and unusual seizures. It is one of the most widely recognized neurological messes, influencing a huge number of individuals around the world. A biomarker is characterized as a dispassionately estimated normal for an ordinary or obsessive natural interaction. Recognizable proof and legitimate approval of biomarkers of epileptogenesis, the improvement of epilepsy, and ictogenesis, the affinity to create unconstrained seizures, may foresee the improvement of an epilepsy condition; recognize the presence and seriousness of tissue equipped for producing unconstrained seizures; measure movement after the condition is set up; furthermore, decide pharmacoresistant. Such biomarkers could be utilized to make creature models for more savvy screening of potential antiepileptogenic and antiseizure medications and gadgets, and to lessen the expense of clinical preliminaries by enhancing the preliminary populace, and going about as proxy markers to abbreviate the preliminary span. The destinations of the biomarker subgroup for the London Studio were to characterize approaches for distinguishing conceivable biomarkers for these reasons. Examination to recognize dependable biomarkers may likewise uncover basic instruments that could serve as helpful focuses for the improvement of new antiepileptogenic and antiseizure compounds.</p> ATUL A. BARAVKAR SAGAR D. SHINDE NITIN B. AHER Copyright (c) 2021 ATUL BARAVKAR, Mr; Dr 2021-12-01 2021-12-01 10.22159/ijpps.2022v14i1.43306 IMPACT OF ACNE VULGARIS ON A PERSON’S QUALITY OF LIFE AND IT’S CORRELATION WITH THE CLINICAL SEVERITY PRE AND POST DRUG THERAPY <p><strong>Objective: </strong>The aim of the study is to assess the therapeutic efficacy of drugs used in acne vulgaris by measuring the severity of acne using the Global Acne Grading System score (GAGS) and Cardiff Acne Disability Index (CADI) questionnaire score pre and post drug therapy.</p> <p><strong>Methods</strong>: The present study was conducted in the Department of Dermatology after getting approval from the Institutional Ethics Committee (No MC/ 190/2007/Pt1/MAR-2019/PG/123) dated 10/04/2019. It was an observational study for a period of 1 year . 172 patients were enrolled in the study. Patients were divided into 4 grades depending on their clinical manifestation .The severity of acne vulgaris and the quality of life was measured using the GAGS scale and the CADI questionnaire respectively at the first visit and at the follow up visit in all the grades of acne vulgaris. A correlation was done between the GAGS and the CADI score at the follow up visit in all grades of acne.</p> <p><strong>Results: </strong>It was observed that the GAGS score and the CADI score was significantly improved at the F/U visit ( p &lt; 0.05) as compared to baseline in all the 4 grades of acne . A correlation between GAGS score and QoL using CADI scale was done using Pearson Parametric Correlation Test. In none of the groups, correlation was significant (p &gt; 0.05).</p> <p><strong>Conclusion:</strong> We can conclude from our study that following treatment with drugs , the clinical severity of acne decreased and there was also significant improvement in the quality of life of patients.</p> SWOPNA PHUKAN SAHELI DAS Copyright (c) 2021 Saheli Das, Swopna Phukan 2021-12-01 2021-12-01 10.22159/ijpps.2022v14i1.43256