International Journal of Pharmacy and Pharmaceutical Sciences
https://journals.innovareacademics.in/index.php/ijpps
<div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div>Innovare Academic Sciences Pvt Ltden-USInternational Journal of Pharmacy and Pharmaceutical Sciences2656-0097PREPARATION AND CHARACTERIZATION OF FLUCONAZOLE TOPICAL NANOSPONGE HYDROGEL
https://journals.innovareacademics.in/index.php/ijpps/article/view/50589
<p><strong>Objective</strong>: The study aimed to develop a polymeric nanosponge-based hydrogel system for enhanced topical application of fluconazole, an antifungal drug.</p> <p><strong>Methods</strong>: Nanosponges were formulated using the emulsion solvent diffusion method using various polymers like hydroxypropyl methylcellulose, ethylcellulose and Eudragit RS 100. Polyvinyl alcohol and ethanol were used to prepare the aqueous and dispersed phases. Nanosponges were dispersed in appropriate amount of gelling agent Carbopol 940 to get nanosponge gel. Drug–polymer interaction has been carried out by FTIR spectroscopy. The prepared nanosponges were evaluated for various tests like production yield, drug entrapment efficiency, compatibility and SEM studies. The nanosponge hydrogel was tested for pH, drug content, spreadability, in-vitro diffusion and kinetic studies.</p> <p><strong>Results</strong>: The drug entrapment efficiency of fluconazole nanosponges was found in the range of 52.3 ± 0.84% to 80.8 ± 0.36% for all formulations respectively. The spreadability of prepared nanosponges gel formulation was in the range between 5.20±0.19 to 7.187±0.85.</p> <p>Particle size analysis showed that the average particle size of fluconazole nanosponges formulated using ethyl cellulose (F5) was found to be 334 nm. The zeta potential was found to be -10.4 mV indicating the formulated fluconazole nanosponges (F5) had moderate stability. FTIR and DSC studies of pure drug and nanosponges suggested that the formulations were stable and there was no chemical interaction with polymer and other excipients. The optimised fluconazole topical nanosponge hydrogel (FG5) released 90.90% drug in 8 h.</p> <p><strong>Conclusion</strong>: Fluconazole topical nanosponge hydrogel could be successfully prepared by emulsion solvent diffusion method. Fluconazole topical nanosponge hydrogel showed promising results under in-vitro condition and thus there exists a scope for evaluation of the developed nanosponge hydrogel for further pharmacokinetic studies, using appropriate test models.</p>SARFARAZ MDSHAIKH ZAMIRULLAH MEHBOOBH. DODDAYYA
Copyright (c) 2024 SARFARAZ MD, SHAIKH ZAMIRULLAH MEHBOOB, H. DODDAYYA
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2024-03-012024-03-0110.22159/ijpps.2024v16i4.50589SICKLE CELL DISEASE IN JHABUA AND KHARGONE DISTRICT: UNVEILING PREVALENCE AND SEVERITY
https://journals.innovareacademics.in/index.php/ijpps/article/view/50497
<p><strong>Objective: </strong>To assess the prevalence among Sickle cell disease (SCD)affected individuals emphasizing the neglected health challenges in various tribes.</p> <p><strong>Methods: </strong>Cross-sectional, observational study was conducted during the district residency program for 9 months. The data has been collected from the record room of patients diagnosed with Sickle cell Anemia. Statistical analysis was done using Microsoft Excel.</p> <p><strong>Results: </strong>A total of 295 patient’s data revealed demographic skew toward Jhabua (50%), with Sickle cell anemia diagnosed at the mean age of 23 ± 3.9. Most patients (72.3%) were Hindu, with Bhil and Bhilaya tribes having higher frequencies. Symptoms varied, 94% had Sickle cell trait, 16.3% had sickle cell disease, and 60% experienced painful crises. Treatment included prophylactic care for all, 37.57% required blood transfusions and 29.7% were on hydroxyurea.</p> <p><strong>Conclusion: </strong>The study underscores the significant SCD burden and the need for heightened awareness and targeted interventions in socio-economically disadvantaged tribal regions to mitigate the impact of SCD.</p>RUCHI KUMARIANJALI KUSHWAHAVINA KHARATNARLAPATI VIGNANSIDDHARTH OJHAAKASH MISHRAPAROMA SINHA
Copyright (c) 2024 RUCHI KUMARI, ANJALI KUSHWAH, AVINA KHARAT, NARLAPATI VIGNAN, SIDDHARTH OJHA, AKASH MISHRA, PAROMA SINHA
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2024-02-262024-02-2610.22159/ijpps.2024v16i4.50497ANTIFUNGAL STEWARDSHIP: MITIGATING INAPPROPRIATE PRESCRIPTIONS IN VULVOVAGINAL CANDIDIASIS IN TERTIARY CARE HOSPITAL, CENTRAL INDIA
https://journals.innovareacademics.in/index.php/ijpps/article/view/50496
<p>This study aims to reduce the inappropriate prescriptions of antifungal medications for vulvovaginitis candidiasis in a tertiary care hospital in central India. An ambispective, observational study was conducted in the Department of Pharmacology of MGM Medical College and Maharaja Yashwantrao Hospital in Indore, MP, over three months (i.e.,12 weeks from August to October 2023). The study encompassed a retrospective analysis of prescriptions for vaginal candidiasis over a period of five weeks in August-September 2023, followed by a prospective analysis over the subsequent five weeks of September-October 2023post-implementation of interactive training sessions, discussions, and antifungal guidelines for two weeks. From a total of 130 randomly selected prescriptions, 69 prescriptions were perused retrospectively while 61 prescriptions received prospective analysis. The post-implemented audit showed a marked reduction in antifungal prescriptions with a difference of 12.4%. An increase in the documentation of examination findings was also observed, from 46.7% to 69.7%. This implementation successfully mitigated inappropriate prescriptions of antifungals, with sustained reductions demonstrated over the 3 months of the study period, emphasizing the effectiveness of educational interventions.</p>NARLAPATI VIGNANVIKALP TIWARIAVINA KHARATRUCHI KUMARI
Copyright (c) 2024 NARLAPATI VIGNAN, VIKALP TIWARI, AVINA KHARAT, RUCHI KUMARI
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2024-03-012024-03-0110.22159/ijpps.2024v16i4.50496