International Journal of Pharmacy and Pharmaceutical Sciences https://innovareacademics.in/journals/index.php/ijpps <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> en-US editor@ijppsjournal.com (Editor) anchal@innovareacademics.in (Anchal) Fri, 01 Oct 2021 14:51:29 +0530 OJS 3.3.0.8 http://blogs.law.harvard.edu/tech/rss 60 LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY DETERMINATION METHOD OF BENCYCLOQUIDIUM BROMIDE: APPLICATION TO DRUG INTERACTION STUDY IN HUMAN https://innovareacademics.in/journals/index.php/ijpps/article/view/43232 <p><strong>Objective: </strong>This study was conducted to develop a sensitive and effective LC-MS/MS method for the determination of bencycloquidium bromide (BCQB) and its application in pharmacokinetic drug interaction study between BCQB and paroxetine.</p> <p><strong>Methods: </strong>The chromatographic separation was performed on Hedera ODS-2 C18 column with a mobile phase consisted of acetonitrile-10 mmol/l ammonium acetate containing 0.2% acetic acid (33:67, v/v) at 550 μl/min, and the plasma samples were processed using solid-phase extraction. The MS/MS transitions were <em>m/z</em> 330.2 → 142.0 for BCQB and <em>m/z</em> 344.2 → 156.1 for the I. S in positive ESI mode.</p> <p><strong>Results: </strong>The validated method was linear over the concentration range of 2-1200 pg/ml with the correlation coefficient <em>r<sup>2</sup></em>&gt;0.998. The intra-and inter-batch precisions of the assay were lower than 8.2% and 9.1%, respectively. The lower limit of quantification (LLOQ) was 2 pg/ml. The stability data at different storage conditions of BCQB were within±5% RE. The mean <em>AUC</em><sub>0-36</sub> of BCQB was increased by approximately 33%, after the administration of BCQB alone and upon co-administration with paroxetine during the drug interaction study.</p> <p><strong>Conclusion: </strong>The LC-MS/MS method validated in this study was robust, reproducible, accurate, precise and reliable and was successfully applied in the pharmacokinetic drug interaction studies.</p> JANVIER ENGELBERT AGBOKPONTO, LOCONON ACHILLE YEMOA, ASSOGBA GABIN ASSANHOU, RUIJUAN LIU, HABIB GANFON, LI DING Copyright (c) 2021 JANVIER ENGELBERT AGBOKPONTO, LOCONON ACHILLE YEMOA, ASSOGBA GABIN ASSANHOU, RUIJUAN LIU, HABIB GANFON, LI DING https://creativecommons.org/licenses/by/4.0 https://innovareacademics.in/journals/index.php/ijpps/article/view/43232 Fri, 01 Oct 2021 00:00:00 +0530 IN VITRO ASSESSMENT OF PHYSICOCHEMICAL PARAMETERS OF FIVE GENERICS AMLODIPINE BESYLATE TABLETS MARKETED IN YEMEN https://innovareacademics.in/journals/index.php/ijpps/article/view/42898 <p><strong>Objective: </strong>The present paper aims to evaluate the quality of five different brands (local and imported) of oral film-coated tablets of generic Amlodipine besylate 5 mg marketed in Sana`a-Yemen, through physiochemical parameters. </p> <p><strong>Methods: </strong>Different physicochemical parameters including the uniformity of tablet weight, hardness, thickness, disintegration time, and an assay of active ingredients were conducted to validate the quality of generics Amlodipine Besylate 5 mg according to USP specification.</p> <p><strong>Results: </strong>From the obtained results, it was observed that all the brands of Amlodipine Besylate 5 mg have passed the tests and met the specifications of USP. Results of weight variation, hardness, thickness, and disintegration time were ranged from -3.8 % to + 5.13 % to -1.25 % to +3.25 %, 5.06 ± 0.31 to 13.21 ± 1.5, 2.682 ± 0.04 to 3.676 ± 0.01 and 25 s to 2 min:30 s, respectively. The dissolution test and the assay results of all the brands are also ranged within the acceptable label claim 93.7 ± 2.24 to 98.4 ± 0.85 and 93.22 ± 0.38 to 100.15 ± 0.33, respectively. However, there is no relation was found between the disintegration time and the dissolution test.</p> <p><strong>Conclusion: </strong>According to the finding, all the selected Amlodipine Besylate 5 mg brands are met pharmacopeia standards and USP specifications. Therefore, the local and imported Amlodipine Besylate 5 mg can be used safely to get the desired therapeutic efficiency.</p> ARWA ALSHARGABI Copyright (c) 2021 ARWA ALSHARGABI https://creativecommons.org/licenses/by/4.0 https://innovareacademics.in/journals/index.php/ijpps/article/view/42898 Mon, 04 Oct 2021 00:00:00 +0530 ESTIMATION OF RESIDUAL SOLVENTS IN NETUPITANT API BY HEADSPACE GAS CHROMATOGRAPHY https://innovareacademics.in/journals/index.php/ijpps/article/view/42781 <p><strong>Objective: </strong>Residual solvents are undesirable components present in Active Pharmaceutical Ingredients (API), excipients, or drug products. To meet the specific quality-based requirements, the presence of these solvents in pharmaceutical products should be monitored to ensure their safety. The main objective of this work is to develop a new method for the determination of residual solvents in netupitant API by an HS-GC method with an FID detector.</p> <p><strong>Methods: </strong>An automated headspace GC method has been developed and validated for the estimation of the residual solvents- N-methyl pyrrolidine, xylene, toluene, and N, N Dimethylacetamide in netupitant API. The samples were dissolved in dimethyl sulfoxide and</p> <p>the equilibrium headspace gas was formed at 80℃ which was analyzed using a DB-624</p> <p>column (30m*0.53mm, 3.00µm) with injector and detector temperature set at 160℃ and 230℃ respectively. The initial oven temperature was set at 60℃ for 5mins and programmed at a rate of 10℃/min to the final temperature of 150℃, with a hold time of 5mins by maintaining the flow rate of 4.0ml/min with a split ratio of 1:10, and total run time of 20mins. Nitrogen was used as carrier gas. The method developed was validated as per International Conference for Harmonization (ICH) guidelines for repeatability, linearity, range, ruggedness, detection limit, quantification limit, and recovery studies.</p> <p><strong>Results: </strong>The linearity range selected was 50-350µg/ml and the correlation coefficient(γ<sup>2</sup>) values for all the solvents were found to be &gt;0.99; recovery studies values were in a range of 90-110% and %RSD values were also found to be not more than 10 for the solvents.</p> <p><strong>Conclusion: </strong>A novel, accurate, sensitive, and simple method was described for estimating residual solvents in Netupitant API by Headspace Gas Chromatography (HS-GC) coupled with a Flame Ionization Detector (FID). Excellent results have been observed for all the validated parameters with good peak resolution and lesser retention times.</p> SUNNY GRACE GODE, VIJAYA LAKSHMI G. Copyright (c) 2021 SUNNY GRACE GODE, VIJAYA LAKSHMI G. https://creativecommons.org/licenses/by/4.0 https://innovareacademics.in/journals/index.php/ijpps/article/view/42781 Fri, 17 Sep 2021 00:00:00 +0530