International Journal of Pharmacy and Pharmaceutical Sciences <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> en-US (Editor) (Anchal) Tue, 01 Nov 2022 10:27:10 +0530 OJS 60 STUDY THE PRODUCTION OF PEDIOCIN BY PEDIOCOCCUS ACIDILACTICI IN REPEATED FED-BATCH FERMENTATION MODE ON MEAT PROCESSING WASTE <p><strong>Objective:</strong> The production of pediocin has been studied in a repeated fed batch reactor with intermittent feeding. The producer strain of pediocin was <em>Pediococcus acidilctici</em>. Meat processing waste was used as nutrient in growth media.</p> <p><strong>Methods: </strong>Repeated fed batch fermentation has been conducted in a bioreactor with three recycle ratio, such as 0.1, 0.2 and 0.3. A mathematical model has been developed for the prediction of reactor behaviour. The antimicrobial activity of pediocin was expressed as arbitrary units per millilitre (AU/ml). The concentrations of biomass, lactic acid, glucose and protein have also been measured with respect to time. </p> <p><strong>Results:</strong> The experimental results were matched well with predicted data. The correlation coefficient (R<sup>2</sup>) was in between 0.95 to 0.97. The maximum productivity of pediocin was obtained 457,200 AU/h for 0.2 recycle ratio.</p> <p><strong>Conclusion: </strong>The model was validated for high accuracy prediction. The study should be applicable for large scale pediocin production.</p> BARNALI MANDAL Copyright (c) 2022 Barnali Mandal Sat, 22 Oct 2022 00:00:00 +0530 IN VITRO ANTIPLATELET ACTIVITY OF AN ISOFLAVANONE ISOLATED FROM METHANOLIC EXTRACT OF EMBLICA OFFICINALIS FRUITS <p><strong>Objective: </strong>In this study, we aimed to isolate a polyphenolic compound from a polyphenolic-rich fraction from <em>Emblica officinalis</em> fruits and also study its effect on adenosine diphosphate (ADP) and collagen-induced<em> in vitro</em> platelet aggregation.</p> <p><strong>Methods: </strong>The polyphenolic-rich fraction was prepared by 80% methanolic extraction. The residue was extracted successively with hexane, benzene, ethyl acetate and n-butanol. Ethyl acetate residue was selected for column chromatography because of its high polyphenolic content. It was subjected to repeated column chromatography of series with different eluents of increasing polarity. A brown amorphous powder was obtained from ethyl acetate: methanol (7:3) fraction. This sample was subjected to UV-visible spectrum, IR spectrum, <sup>1</sup>H NMR, <sup>13</sup>C NMR and electrospray mass spectrum (ES-MS) studies for its structural elucidation.</p> <p><strong>Results: </strong>A compound, 5, 7, 4'-trihydroxy 3'-methoxy isoflavanone was identified from polyphenolic rich ethyl acetate: methanol (7:3) fraction separated from the 80% methanolic extract of <em>Embica officinalis</em> fruits by repeated column chromatography. Yield of the compound was 421.05 mg/kg. This compound exhibited antiplatelet activity well comparable with that of quercetin.</p> <p><strong>Conclusion: </strong>The present study proved that the isolated compound 5, 7, 4'-trihydroxy 3'-methoxy isoflavanone exerts a significant inhibitory activity on ADP and collagen-induced <em>in vitro</em> platelet aggregation, which can be considered as an effective remedy for alleviating complications of cardiovascular diseases.</p> ANILA L., M. S. HASHIM Copyright (c) 2022 ANILA L., M. S. HASHIM Tue, 01 Nov 2022 00:00:00 +0530 A PROSPECTIVE OBSERVATIONAL STUDY ON PREVALENCE AND TREATMENT OF URINARY TRACT INFECTIONS IN A TERTIARY CARE TEACHING HOSPITAL IN TELANGANA STATE <p><strong>Objective</strong>: To study the Prevalence of urinary tract infections and related risk factors and to study the Management of urinary tract infections.</p> <p><strong>Methods</strong>: This was a prospective observational study conducted in General Medicine Department, Osmania General Hospital(OGH), a tertiary care teaching hospital in Telangana State,where patients presenting or highly suspicious of having UTIs were included in the study. Pregnant women, Children, Patients who are not willing to participate were excluded from the study. Data was collected in a predesigned Data collection forms.</p> <p><strong>Results</strong>: Over a period of 6 Months a total of 75 UTI cases were observed, in General Medicine Department of OGH, which included 33 Males, and 42 Females. High prevalence of UTI were observed in Females in the middle age group i.e. 31-45 years whereas in Males, in senior adult group i.e., &gt;60 years .The age group 18-30 years have shown the dominance of Uncomplicated UTIs(19%) and Primary UTIs (17%) and the age group &gt;60 years have shown the dominance of Complicated UTIs (25%) and Recurrent UTIs( 23%). The most common causative organism was found to be E.coli (69.3%).It was confirmed that the most common risk factor was found to be Diabetes Mellitus followed by Hypertension and Chronic Kidney Disease. The most common antibiotic prescribed for UTI was Piperacillin+ Tazobactum and for fungal UTIs, antifungal drug i.e., Fluconazole was prescribed.</p> <p><strong> Conclusion:</strong> E.coli are the major cause of UTIs among patients It is discovered that UTI is common among the females.Hospitalisation, married individuals,Diabetes mellitus, genitourinary tract abnormalities,congestive cardiac failure, hypertension, prostatitis and female gender are the most important risk factors of UTIs.Appropriate measures may help to reduce UTIs due to these associated factors.</p> SYEDA RANA NIKHAT, JUVEYRIA KAREEM, ASMA LATEEF, SYEDA RUHI FATIMA, RAFIA SULTANA Copyright (c) 2022 Rana Nikhat Syeda, Juveyria kareem, Asma Lateef, Syeda Ruhi Fatima, Dr.Rafia Sultana Sat, 22 Oct 2022 00:00:00 +0530