International Journal of Pharmacy and Pharmaceutical Sciences <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> en-US (Editor) (Anchal) Sat, 01 Jan 2022 11:24:53 +0530 OJS 60 ROLE OF ANTIDEPRESSANTS AGAINST LEISHMANIASIS <p>The disease, Leishmaniasis is a forlorn, tropical, vector-borne disease caused by the kinetoplast protozoan, an obligate intracellular parasite of the class Leishmania which is transmitted by the nibble of female sandfly (Phlebotomus). Leishmaniasis is an incurable rare disease, since the organism developed resistance towards the currently used drugs, including pentavalent antimonials, amphotericin B and miltefosine. The mechanisms involved in drug resistance include reduced expression and mutations in AQP1, mutations in miltefosine transporters like, LMT and/or LRos3 and increased expression of drug efflux transporters like, ABC transporters in the parasitic cells. Hence alternate therapeutics against leishmaniasis is the need of the hour. Here we discuss the therapeutic potential of antidepressants as potential antileishmanial agents.</p> KEYA MALLICK, SUGATO BANERJEE Copyright (c) 2022 Sugato Banerjee, Keya Mallick Thu, 20 Jan 2022 00:00:00 +0530 A CASE PRESENTATION ON OFLOXACIN INDUCED DERMAL HYPERSENSITIVITY REACTION <p>Ofloxacin is a second-generation fluoroquinolone and is highly effective against a wide range of bacterial infections. Fluoroquinolones are well-tolerated drugs with mild-to-moderate adverse effects such as gastrointestinal disturbances, skin reactions, and neurological reactions. These are widely used antimicrobials, which can cause cutaneous ADRs in about 1%–2% of patients. Hypersensitivity reactions due to ofloxacin are found rarely, ranging in frequency from 0.4% to 2%, respectively. This case report highlights one such event of cutaneous ADR by the use of ofloxacin injection causing Injection site reaction after a few minutes of Ofloxacin infusion. Based on history and clinical examination patient was diagnosed as ofloxacin induced hypersensitivity reaction and was successfully treated with antihistamines and corticosteroids. General management of ADR includes withdrawal/suspension, dose reduction of the suspected drug, and administration of supportive therapy. In this case, the suspected drugs were withdrawn and the patient was treated symptomatically. Pharmacovigilance should be a part of patient care to reduce the occurrence of adverse drug reactions and also encourage practitioners in reporting to gather more and more data regarding adverse drug reactions.</p> <p>Due to the rarity of Ofloxacin induced ADRs this article sheds light on one of such cases to help in pharmacovigilance</p> BHAVANAM DIVYA, LEDO THANKACHAN Copyright (c) 2022 Divya Bhavanam, Ledo Thankachan Thu, 20 Jan 2022 00:00:00 +0530 DEVELOPMENT OF NANOPARTICLES SUSPENSION FOR PAEDIATRIC DRUG ADMINISTRATION <h3>Objective: Enalapril maleate (EM) is an angiotensin-converting enzyme (ACE) inhibitor. It is generally prescribed for the treatment of hypertension, heart failure and chronic kidney diseases in adults and children. EM 2.5mg, 5mg, 10mg and 20mg tablets and EM injection 1.25 mg/ml are currently available in the market. But a liquid paediatric formulation of this medicine is not currently available. Also, it is a BCS class III drug, having a bioavailability of approximately 60%. The present study proposes a new strategy for improvement of drug bioavailability and taste masking: EM nanoencapsulation within polymeric nanoparticles suspensions prepared with Eudragit RS100 (ERS100) as polymer and Tween 80 as a stabilizer, aiming at obtaining a liquid dosage form suitable for paediatric administration.</h3> <h3>Methods: Nanoprecipitation method used for the preparation of nanoparticles suspension. The preparations were evaluated for drug content, entrapment efficiency, particle size, zeta potential, polydispersity index, pH, viscosity and <em>in vitro</em> drug release. Based on the entrapment efficiency, viscosity and <em>in vitro</em> drug release the optimized formulation was selected. Optimized formulation evaluated for taste, <em>ex vivo</em> intestinal permeation, differential scanning calorimetry, scanning electron microscopy and release kinetic studies.</h3> <h3>Results: The optimized nanoparticle formulation F8 having drug to polymer ratio of 1:100 showed satisfactory drug content (95.1%), entrapment efficiency (77.71%), particle size (198.47 nm), pH (6.36), viscosity (2.9 x Pa·s) and 81.2% drug release after 12 hours. The formulation has taste-masking properties and shows 84.6% drug permeation through the goat intestine within 12 hours.</h3> <p class="s14"><strong>Conclusion:</strong> The prepared nanoparticles suspension of Enalapril maleate was found to be an effective liquid pharmaceutical dosage form for paediatric administration with taste-masking properties.</p> K. K. RAJULA, JISHA MOHANAN Copyright (c) 2021 K. K. RAJULA, JISHA MOHANAN Tue, 28 Dec 2021 00:00:00 +0530