Thematic Issue "Drugs from Nature"

Special Issue 1 for International Journal of Pharmacy and Pharmaceutical Sciences (IJPPS)

Theme

Drugs from Nature: Plants as an important source of pharmaceutically important metabolites

Guest Editor: Dr. Dhananjaya Bhadrapura Lakkappa

Aims & Scope:

Natural products are a constant source of potentially active compounds for the treatment of various disorders. A number of pharmaceutical drugs were designed, based on natural compounds and used for their therapeutic potential. There are several hundreds of drugs being designed and developed based on plant secondary metabolites all over the world. It should also be highlighted that plants (or their parts) are used as infusions, tincture, or in the form of crude extracts for treatment of human disorders (St. John wort utilized in the treatment of mild to moderate depressions; Devil’s claw against inflammations, just to name a few).The World Health Organization estimates that 4 billion people (i.e. 80% of the World’s population) use herbal medicines in some aspects of primary healthcare and there is a growing tendency to “Go Natural”, which altogether comprise an annual market of several billion US dollars. This has opened up a huge and potential window for research and challenges a number of scientists in exploring the (still) hidden part of nature in searching for new drug leads. It is to be noted that currently an about half of the plant species have been described as only 10% of them have been chemically investigated.

The main goal of this special issue is to discuss the current advancements in the development of identifying and developing drug leads from plants for prevention of socio-significant diseases, an area a bit neglected, but proven to be very important by several (epidemiological) studies, their medicinal chemistry, and mechanism of action. Further, it highlights the therapeutical potential of various plants and/or their metabolites in treatment of diseases. It also focuses to cover some modern and emerging techniques for leads finding (e.g. so-called ‘omics’ approaches) and mass production of pharmaceutically important metabolites (e.g. Taxol case; therapeutic recombinant proteins and edible vaccines).

The special issue will encompass a selection of invited systematic and narrative reviews, original research and editorials written by experts in the field across the globe.

Keywords:

Plants, drugs, medicinal chemistry, pharmaceutical, Omics approaches, metabolites, diseases.

Subtopics:

- Therapeutical potential of various plants and/or their metabolites in treatment of various diseases

- Diverse approaches/methodologies for identifying and developing therapeutic leads.

- Metabolites from plants as therapeutical potential candidates against various socio-significant diseases such as cancer, diabetes, Alzheimer’s disease etc..,

- New high-throughput technologies, bioinformatics analysis, computational analysis, omics and nanotechnological approaches in drug discovery for better treatment and management of socio-significant diseases such as cancer, diabetes, Alzheimer’s disease etc..,

- Novel proteomics/nano-technological methodologies in the discovery of therapeutic leads

- Inhibitors therapeutic prospects

Schedule:

Manuscript submission deadline:	April 25, 2015
Peer Review Due:	May 20, 2015
Revision Due:	June 25, 2015
Notification of acceptance by the Guest Editor:	July 15, 2015
Final manuscripts due:	August 22, 2015

Contact:

Dr. B.L. Dhananjaya,

Toxinology/Toxicology and Drug Discovery Unit

Center for Emerging Technologies, Jain Global Campus

Jain University, Jakksandra post, Kanakapura Taluk,
Ramanagara 562112, Karnataka, India.

Email ID: chandu_greeshma@rediffmail.com

Instructions to authors

Type-written manuscripts prepared using MS Word should be submitted by online submission system (http://innovareacademics.in/journals/index.php/ijpps/about/submissions#onlineSubmissions)

Manuscripts will be subjected to peer review process to determine their suitability for publication provided they fulfill the requirements of the journal as laid out in the instructions to authors. After the review, manuscripts will be returned for revision along with reviewer’s and/or editor’s comments. Prepare the manuscript in Times New Roman font using a font size of 12. There shall not be any decorative borders anywhere in the text including the title page.
All the tables and figures should be in the text at suitable place.

Submission of a manuscript to International Journal of Pharmacy and Pharmaceutical Sciences for publication implies that the same work has not been either published or under consideration for publication in another Journal. Authors, in their cover note to the Editor, have to clearly mention whether the manuscript shall be considered as a Research Paper, Short Communication or Review Article and also confirm that the manuscript has not been submitted to any other Journal for publication. Authors publishing results from in vivo experiments involving animals or humans should state whether due permission for conduction of these experiments was obtained, from the relevant ethics committees, in the Materials and Methods section. In addition, authors wishing to publish research work involving human studies should also send a notary verified letter of approval from the Ethics Committee or the Institutional Review Board.

Manuscript should be divided into Title page, Abstract, Introduction, Materials and Methods, Results, Discussion or Results and Discussion, conclusions, Acknowledgements, References.

Title page- In separate lines, title page should contain the title of the manuscript, the name(s) and affiliation(s) of the author(s), and the mailing address, telephone and fax numbers, and e-mail address of the corresponding author. The title must be specific, concise and informative.

Title - HEPTOPROTECTIVE ACTIVITY OF -----------(12 FONT SIZE, TIMES NEW ROMAN, NORMAL, BOLD)
Authors - Avijeet Jain, Amit K Jain ---(12 FONT SIZE, TIMES NEW ROMAN, NORMAL, BOLD)

Keywords and abstract- Please include 3-10 keywords for indexing purposes; Full-length manuscript submission should contain an abstract of up to 250 words in a structured form, consisting of: Objective, Methods, Results, and Conclusion.

Headings – INTRODUCTION, MATERIALS AND METHODS, RESULTS, DISCUSSION, CONCLUSIONS.

Subheadings- Preparation of extracts

Introduction- It should summarize the rationale, provides a concise research background (not an exhaustive review) and states in single sentence the objective of the study. Please do not include any results or the conclusions of the study.

Materials and methods- All the ethical permission associated in the research work must be specified. It should provide technical information about the study. Published methodological details are not needed to describe that have been published previously. Specifications (including the manufacturer, city, and the country) should be given for the main drugs, chemicals, and instruments. Indicate the statistical methods used and identify statistical significance using superscripts (* and **) following the data (*P < 0.05, **P < 0.01).

Results- It should reveal the findings of works.

Discussion- It should be with the interpretation of the results and their comparison with those of other studies. No need to repeat the results, review literature, textbook knowledge or cite references that do not have a close relationship with the present result.

Conclusions – conclude the study linking back to the aim of the study.

Abbreviations- At the first appearance in the abstract and the text, abbreviations should be preceded by words for which they stand.

Tables- Tables must be concise and cited consecutively using Arabic numerals in the text (Table 1, Table 2...etc.). The title of the table should clearly indicate the nature of the contents and sufficient detail should be included in the footnote to facilitate interpretation without reference to the text. Use horizontal rules only.

Table Format – It should be designed using table tools of MS Word and exactly same as below

Table 1: It shows ---(12 font size, times new roman, normal, bold)

Groups	Change in body weight (gm)
Control
Negative control
Protective
Curative

Figures -Figures (photographs, drawings, diagrams and charts) should be clear, easily legible and cited consecutively using Arabic numerals in the text(Figure 1, Figure 2...etc.). Please supply figures 1.5 to 2 times the size at which they will be finally reproduced. For line work, submit black-ink drawings of professional quality. Micrographs or other glossy photographs must be of the highest quality. Use standard symbols: â—‹, â—, ×, â–¡, â– , â–³, â–². Freehand or typewritten lettering is unacceptable. If a figure comprises more than one glossy photograph, these should be marked A, B, C...etc. Figure legends should be marked clearly with their correspond letters. Legends should contain sufficient detail to permit figure interpretation without reference to the text. Scale markers should be indicated in the photographs. Color plates are also welcome. The choice of cover art illustration will be made by the Editor.

Figure format –

Fig. 1: It Shows ---(12 Font size, Times New Roman, Normal, Bold)

Manuscripts that fail to conform to the requirements of the Journal, as specified under 'Instructions to Authors', will be rejected outright.

References

References should be numbered consecutively in the order in which they are first mentioned in the text (not in alphabetic order). Identify references in text, tables, and legends by Arabic numerals in parenthesis/bracket like- [1]. References cited only in tables or figure legends should be numbered in accordance with the sequence established by the first identification in the text of the particular table or figure. Use the style of the examples below, which are based on the formats used by the NLM in Index Medicus. The titles of journals should be abbreviated according to the style used in Index Medicus. Use complete name of the journal for non-indexed journals. Avoid using abstracts as references. Information from manuscripts submitted but not accepted should be cited in the text as “unpublished observations” with written permission from the source. Avoid citing a “personal communication” unless it provides essential information not available from a public source, in which case the name of the person and date of communication should be cited in parentheses in the text. For scientific articles, contributors should obtain written permission and confirmation of accuracy from the source of a personal communication.

The commonly cited types of references are shown here, for other types of references such as electronic media, newspaper items, etc. please refer to ICMJE Guidelines (http://www.icmje.org).

Articles in Journals

Devi KV, Pai RS. Antiretrovirals: Need for an Effective Drug Delivery. Indian J Pharm Sci 2006;68:1-6. List the first six contributors followed by et al.
Volume with supplement: Shen HM, Zhang QF. Risk assessment of nickel carcinogenicity and occupational lung cancer. Environ Health Perspect 1994;102 Suppl 1:275-82.
Issue with supplement: Payne DK, Sullivan MD, Massie MJ. Women’s psychological reactions to breast cancer. Semin Oncol 1996;23(1, Suppl 2):89-97.

Books and Other Monographs

Personal author(s): Ringsven MK, Bond D. Gerontology and leadership skills for nurses. 2nd ed. Albany (NY): Delmar Publishers;1996.
Editor(s), compiler(s) as author: Norman IJ, Redfern SJ, editors. Mental health care for elderly people. New York: Churchill Livingstone;1996.
Chapter in a book: Phillips SJ, Whisnant JP. Hypertension and stroke. In: Laragh JH, Brenner BM, editors. Hypertension: pathophysiology, diagnosis, and management. 2nd ed. New York: Raven Press; 1995. p. 465-78.

Short Communication

The journal publishes exciting findings, preliminary data or studies that did not yield enough information to make a full paper as short communications. These have the same format requirements as full papers but are only up to 5 pages in length. Short Communications should not have subtitles such as Introduction, Materials and Methods, Results and Discussion - all these have to be merged into the running text. Short Communications preferably should have only 3-4 illustrations.

Review Articles

Should be about 18 pages long, contain up-to-date information, comprehensively cover relevant literature and preferably be written by scientists who have in-depth knowledge on the topic. All format requirements are same as those applicable to full papers. Review articles need not be divided into sections such as Materials and Methods and Results and Discussion, but should definitely have an Abstract and Introduction, if necessary.

Conflict of Interest statement

It must be declared by authors.