SYNTHESIS AND BIOLOGICAL ACTIVITIES OF COBALT COMPLEX WITH SCHIFF’SBASE LIGAND DERIVED FROM 4-CHLORO-N-[(E)-PYRIDIN-2-YLMETHYLIDENE] ANILINE

  • SURESH D. DHAGE Dept. of Chemistry, SSJES, Arts, Commerce and Science College, Gangakhed- 431514.Dist. Parbhani (M.S.)

Abstract

4-chloro-N-(E)-pyridin-2-ylmethylidene aniline isprepared by condensing 2-pyridine carboxaldehyde and 4-chloroanilinein ethanol. The Schiff base was reacted with cobalt chloride in acetonitrile and solution of two equivalent of triphenylphospine to obtain the corresponding Cobalt4-chloro-N- [(E)-pyridin-2-ylmethylidene]aniline complex. The synthesised Schiff base and complex were characterized on the basis of their chemical properties and spectroscopic data. These compounds were tested for anticancer,anti-inflammatory activity and antimicrobial activity against a variety of test organisms: Escherichia coli, Staphylococcus aureus, and Candida albicans. The compounds containing chlorogroup as substituents on the phenyl ring have been found to be very effective antimicrobial agents.

Keywords: Schiff base, anticancer, antiinflametry, antimicrobial.etc

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D. DHAGE, S. (2020). SYNTHESIS AND BIOLOGICAL ACTIVITIES OF COBALT COMPLEX WITH SCHIFF’SBASE LIGAND DERIVED FROM 4-CHLORO-N-[(E)-PYRIDIN-2-YLMETHYLIDENE] ANILINE. Innovare Journal of Sciences, 8(7), 65-68. Retrieved from https://innovareacademics.in/journals/index.php/ijs/article/view/38534
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