TY - JOUR AU - VENKAT S., SURYAWANSHI PY - 2020/05/31 Y2 - 2024/03/29 TI - VITAMIN B1PROMOTED GREEN SYNTHESIS OF BENZOFURAN CHALCONES: PROMISING SCAFFOLDS FOR DRUG DEVELOPMENT IN ANTIMICROBIAL JF - Innovare Journal of Sciences JA - Innovare J Sci VL - 8 IS - 7 SE - Articles DO - UR - https://journals.innovareacademics.in/index.php/ijs/article/view/38526 SP - 45-47 AB - <p>&nbsp;<strong>Objective: </strong>To develop metal free and environmentally benign synthetic method for the synthesis of chalcones bearing benzofuran scaffolds<strong>. Materials and Methods:</strong>Starting material chloroacetone,anhydrous potassium carbonate, different aromatic aldehydes, ethanol and vitamin B1 of AR grade wereused for synthesis.Various chalcones were synthesized byClaisen-Schmidt condensation.The structure of the synthesized compounds was confirmed by elemental analysis, IR,1H NMR and mass spectra.</p><p>&nbsp;<strong>Results:</strong>In this context we have tried new metal free and environmentally benign synthetic method for synthesis of the pharmaceutically important molecule 1-(4-substituted-1-benzofuran-2-yl) substituted chalcones and its derivatives and it was screened for their antimicrobial activity.Most of the compounds exhibited the good to moderate activity.</p><p><strong>Conclusion:</strong>Herein we have tried a highly efficient protocol for the synthesis of chalconesa good result with variety of functionalities, a high yield of products, and the recoverability of this catalyst.Vitamin B1 as a catalyst has been developed using green solvent EtOH.</p> ER -