ROLE OF ENZYMES IN THE PATHOGENESIS OF DEPRESSION
Depression is one of the most prevalent neuropsychiatric disorders that occurs due to the alterations in the monoaminergic system of the body. Various factors may be responsible for the alterations in the monoaminergic system. MAO-A is an enzyme which metabolizes the monoamines and thus responsible for the reduction in the level of monoamines in the body. Stress induces the increase expression and levels of various proinflammatory cytokines such as IL-6, IL-1Î², TNF-Î± and PGE2 involved in the pathogenesis of depression.Â These proinflammatory cytokines increase or decrease the activity of various enzymes that further led to the reduction in the serotonin level of the brain. Thus, it has been suggested that the depression which is considered as a disorder that arises due to the imbalance in the neurotransmitters in the brain arises due to the alterations in the activities of the various enzymes. Therefore the aim of present review is to demonstrate the role of the various enzymes in the pathogenesis of depression.
Keywords: Depression, Enzymes, Nitric oxide, Stress.
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