BICELLE: A LIPID NANOSTRUCTURE FOR TRANSDERMAL DELIVERY


Shah Hirva, Patel Jenisha

Abstract


The transdermal delivery is challenging route for drug delivery and henceforth has a narrow range of drug. The effective skin treatments require products able to penetrate the skin gently, remaining there and delivering its benefits in target layers. The permeability is the main barrier for the transdermal delivery system. However, due to certain advantages of the transdermal route, there are numerous transdermal delivery systems available which are managed to penetrate by enhancing skin penetration. Few studies have widened the transdermal approach for hydrophilic, macromolecules and conventional drug for new therapeutic indications. The present review summarizes a new lipoidal nanostructure formulation for the transdermal delivery of drug or cosmetic. Bicelles are formed by a long and a short-chain phospholipid dispersed in aqueous solution. Bicelle provides appropriate size, high stability, and biocompatibility of formulation which makes it a versatile platform that can be applied in different skin disorder. The limitation of Bicelles is in environments with high water content which modify their morphology. A new nanostructure that overcomes its limitations is known as: Bicelle encapsulated liposome, Bicosomes. The specific characteristics of bicelles and their high versatility, the use of these nanostructured lipid systems as a colloidal carrier should be considered. The review presents the method for preparation and evaluation. Bicelles and its modified formulation have a great potential in biomedicine, cosmetics, and term pharmacy.

Keywords: Transdermal delivery, Bicelles, Cosmetics, Bilayer vesicles, Nanostructure


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About this article

Title

BICELLE: A LIPID NANOSTRUCTURE FOR TRANSDERMAL DELIVERY

Date

04-04-2016

Additional Links

Manuscript Submission

Journal

Journal of Critical Reviews
Vol 3, Issue 2, 2016 Page: 17-22

Online ISSN

2394-5125

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206 Views | 1299 Downloads

Authors & Affiliations

Shah Hirva
Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Bardoli 394345
India

Patel Jenisha
Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Bardoli 394345


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