BICELLE: A LIPID NANOSTRUCTURE FOR TRANSDERMAL DELIVERY
The transdermal delivery is challenging route for drug delivery and henceforth has a narrow range of drug. The effective skin treatments require products able to penetrate the skin gently, remaining there and delivering its benefits in target layers. The permeability is the main barrier for the transdermal delivery system. However, due to certain advantages of the transdermal route, there are numerous transdermal delivery systems available which are managed to penetrate by enhancing skin penetration. Few studies have widened the transdermal approach for hydrophilic, macromolecules and conventional drug for new therapeutic indications. The present review summarizes a new lipoidal nanostructure formulation for the transdermal delivery of drug or cosmetic. Bicelles are formed by a long and a short-chain phospholipid dispersed in aqueous solution. Bicelle provides appropriate size, high stability, and biocompatibility of formulation which makes it a versatile platform that can be applied in different skin disorder. The limitation of Bicelles is in environments with high water content which modify their morphology. A new nanostructure that overcomes its limitations is known as: Bicelle encapsulated liposome, Bicosomes. The specific characteristics of bicelles and their high versatility, the use of these nanostructured lipid systems as a colloidal carrier should be considered. The review presents the method for preparation and evaluation. Bicelles and its modified formulation have a great potential in biomedicine, cosmetics, and term pharmacy.
Keywords: Transdermal delivery, Bicelles, Cosmetics, Bilayer vesicles, Nanostructure
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