INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS


Satyavani Kaliamurthi, Gurudeeban Selvaraj

Abstract


Solid lipid nanoparticles (SLNp) are a new class of alternative colloidal carriers developed at the beginning of the 1990s with the particle size ranging from 50 to 1000 nm. The SLNp consists of the drug molecule, surfactants, and solid lipid core suitable for incorporation of lipophilic, hydrophilic, and poorly water-soluble molecules. Diabetes mellitus (DM), is a prototype multifactorial complex diseases that regarded as one as one of the leading causes of morbidity and mortality in the world. DM caused by inadequate secretion of insulin or by the damaged cells of Islet of Langerhans of the pancreas. The present review provides information about the suitable choice of lipid, amount of surfactants was used for SLNp preparation, characterization, and various route of administration to increase the relative oral bioavailability in diabetic animals. Moreover, limitations associated with nanocarrier system for insulin delivery have also been discussed. Solid lipid Nanoparticulate system might be efficiently overcome peripheral hyper insulinemia, lipo-hyper-atrophy and improves the life quality of diabetic patients in the near future.


Keywords


Diabetes mellitus, Palmitic acid, Nanocarrier system, Microscopy

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About this article

Title

INSIGHT ON SOLID LIPID NANOPARTICLES: CHARACTERIZATION AND APPLICATION IN DIABETES MELLITUS

Keywords

Diabetes mellitus, Palmitic acid, Nanocarrier system, Microscopy

Date

01-10-2016

Additional Links

Manuscript Submission

Journal

Journal of Critical Reviews
Vol 3, Issue 4, 2016 Page: 11-16

Online ISSN

2394-5125

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Authors & Affiliations

Satyavani Kaliamurthi
Centre of Advanced Study in Marine Biology, Faculty of Marine Science, Annamalai University, Parangipettai 608502, Tamil Nadu, India
India

Gurudeeban Selvaraj


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