• Jyotibala Banjare Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune (India)


Obesity is a medical condition arises as a result of an imbalance between lipolysis and lipogenesis which leads to accumulation of excess fat. Obesity is linked with major health complications such as diabetes, cardiac disorder, cancer, hypertension, sleep apnoea, etc. Weight loss through medication and healthy food balance can prevent obesity and associated disorders. Though, diet based therapy and drugs have short term effect with lacunae. At present, no reliable and established oral supplements are available to take care of obesity. Nanotechnology is a briskly emerging area of science and technology for food modulation at molecular and atomic level. The unique size and superior properties of nanomaterial have huge application in biology and medicine for food and drug development. Nanotechnology is playing an important role in the food industry for unindustrialized improved food, uptake, absorption, and bioavailability of nutrients to the body. Balanced or better-modified nutrients food, restricted calorie measures and commercial availability is geared through Nanoscience for control of obesity. Nanoparticle Targeted drug therapy, particularly for adipose tissue, may provide a new generation formulation for therapeutics of obesity.

Keywords: Nanofood, Nanomaterial, Drug delivery, Adipose tissue


1. Melnikova I, Wages D. Anti-obesity therapies. Nat Rev Drug Discovery 2006;5:369-70.
2. Elangbam CS. Review paper: current strategies in the development of anti-obesity drugs and their safety concerns. Veterinary Pathol Online 2009;46:10-24.
3. Sanguansri P, Augustin MA. Nanoscale materials development–a food industry perspective. Trends Food Sci Technol 2006;17:547-56.
4. Nickols-Richardson SM. Nanotechnology: implications for food and nutrition professionals. J Am Diet Assoc 2007;107:1494-7.
5. Chen H, Weiss J, Shahidi F. Nanotechnology in nutraceuticals and functional foods. Food technology; 2006.
6. Mela DJ. Implications of fat replacement for food choice and energy balance. Chem Industry 1996;98:329-32.
7. Thovhogi N, Sibuyi N, Meyer M, Onani M, Madiehe A. Targeted delivery using peptide-functionalised gold nanoparticles to white adipose tissues of obese rats. J Nanoparticle Res 2015;17:1-8.
8. Hossen MN, Kajimoto K, Akita H, Hyodo M, Harashima H. A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication. J Controlled Release 2013;171:104-12.
9. Neethirajan S, Jayas DS. Nanotechnology for the food and bioprocessing industries. Food Bioprocess Technol 2011;4:39-47.
10. Ranjan S, Dasgupta N, Chakraborty AR, Samuel SM, Ramalingam C, Shanker R, et al. Nanoscience and nanotechnologies in food industries: opportunities and research trends. J Nanoparticle Res 2014;16:1-23.
11. Singh H, Ye A, Horne D. Structuring food emulsions in the gastrointestinal tract to modify lipid digestion. Progress Lipid Res 2009;48:92-100.
12. Blasco C, Picó Y. Determining nanomaterials in food. TrAC Trends Anal Chem 2011;30:84-99.
13. [Last accessed on 22 Nov 2016]
14. Ozimek L, Pospiech E, Narine S. Nanotechnologies in food and meat processing. Acta Sci Pol Technol Aliment 2010;9:401-12.
15. Chau CF, Wu SH, Yen GC. The development of regulations for food nanotechnology. Trends Food Sci Technol 2007;18:269-80.
16. Pszczola DE. Ingredients for fat replacement. Food Technol 1997;51:82-8.
17. Sozer N, Kokini JL. Nanotechnology and its applications in the food sector. Trends Biotechnol 2009;27:82-9.
18. Ruxton CH, Calder PC, Reed SC, Simpson MJ. The impact of long-chain n-3 polyunsaturated fatty acids on human health. Nutr Res Rev 2005;18:113-29.
19. Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, et al. Applications and implications of nanotechnologies for the food sector. Food Addit Contam 2008;25:241-58.
20. Hahn NI. Replacing fat with food technology. J Acad Nutr Dietetics 1997;97:15.
21. Singh R, Lillard JW. Nanoparticle-based targeted drug delivery. Exp Mol Pathol 2009;86:215-23.
22. Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 2010;10:3223-30.
23. Rocca A, Mattoli V, Mazzolai B, Ciofani G. Cerium oxide nanoparticles inhibit adipogenesis in rat mesenchymal stem cells: potential therapeutic implications. Pharm Res 2014;31:2952-62.
24. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, et al. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci India 2002;99:10730-5.
25. Zhang HL, Zhong XB, Tao Y, Wu SH, Su ZQ. Effects of chitosan and water-soluble chitosan micro-and nanoparticles in obese rats fed a high-fat diet. Int J Nanomed 2012;7:4069.
26. Sharifi S, Daghighi S, Motazacker MM, Badlou B, Sanjabi B, Akbarkhanzadeh A, Rowshani AT, et al. Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes. Sci Rep 2013;3:2173.
27. Rocca A, Moscato S, Ronca F, Nitti S, Mattoli V, Giorgi M, et al. Pilot in vivo investigation of cerium oxide nanoparticles as a novel anti-obesity pharmaceutical formulation. Nanomed: Nanotechnol Biol Med 2015;11:1725-34.
28. Hossen MN, Kajimoto K, Akita H, Hyodo M, Ishitsuka T, Harashima H. Therapeutic assessment of cytochrome c for the prevention of obesity through the endothelial cell-targeted nanoparticulate system. Mol Ther 2013;21:533-41.
29. Hossen MN, Kajimoto K, Akita H, Hyodo M, Harashima H. Vascular-targeted nanotherapy for obesity: unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery. J Controlled Release 2012;163:101-10.
30. Nanoparticles-be-used-for-Weight-Loss.aspx. [Last accessed on 22 Nov 2016]
31. Wyatt SB, Winters KP, Dubbert PM. Overweight and obesity: prevalence, consequences, and causes of a growing public health problem. Am J Med Sci 2006;331:166-74.
32. Weiss J, Takhistov P, McClements DJ. Functional materials in food nanotechnology. J Food Sci 2006;71:R107-16.
33. Nanofood Originator's Blog. Available from: http:// [Last accessed 14 Jan 2015]
34. Eldaw A. Nanotechnology in elevation of the worldwide impact of obesity and obesity-related diseases: potential roles in human health and disease. J Diabetes Sci Technol 2011;5:1005-8.
35. Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R. Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles. Proc Natl Acad Sci India 2016:2:2016038-40.
36. Chaudhry Q, Castle L, Watkins R. Nanotechnologies in food. Royal Society of Chemistry; 2010.
37. Lu J, Liong M, Li Z, Zink JI, Tamanoi F. Biocompatibility, biodistribution, and drug‐delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals. Small 2010;6:1794-805.
38. Ramalingam C, Harshita Jain, Kirti Vatsa, Nausin Akhtar, Bhaskar Mitra, D Vishnudas, et al. Detection and biochemical characterization of microorganisms in milk and cocoa powder samples by FTIR and subsequent production of bacteriocin from lactobacillus. Int J Drug Dev Res 2013;5:310–20.
39. De Jong WH, Borm PJ. Drug delivery and nanoparticles: applications and hazards. Int J Nanomed 2008;3:133.
40. Fisher E. Lessons learned from the ethical, legal and social implications program (ELSI): planning societal implications research for the National Nanotechnology Program. Technol Soc 2005;27:321e328.
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