MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION


Ozaifa Kareem, Nasir Nisar, Nahida Tabassum

Abstract


Constipation disproportionately affects older adults, with a prevalence of 50% in community-dwelling elderly and 74% in nursing-home residents. Loss of mobility, medications, underlying diseases, impaired anorectic sensation, and ignoring calls to defecate are as important as dyssynergic defecation or irritable bowel syndrome in causing constipation. Opioid antagonists not only have well-established indications in the reversal of life-threatening opioid toxicity but also hold considerable promise for other applications in palliative care practice, particularly management of opioid-induced constipation (OIC). This review summarizes the pharmacology of new peripherally acting mu (µ) opioid receptor antagonists (PAMORA).


Keywords


Constipation, Opioid-Induced Constipation (OIC), Opioid receptor antagonists, Methylnaltrexone, Alvimopan, Naloxegol

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References


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About this article

Title

MU-OPIOID RECEPTOR ANTAGONISTS AND THEIR ROLE IN TREATMENT OF CHRONIC CONSTIPATION

Keywords

Constipation, Opioid-Induced Constipation (OIC), Opioid receptor antagonists, Methylnaltrexone, Alvimopan, Naloxegol

DOI

10.22159/jcr.2017v4i4.22260

Date

02-11-2017

Additional Links

Manuscript Submission

Journal

Journal of Critical Reviews
Vol 4, Issue 6 (Oct-Nov), 2017 Page: 1-6

Online ISSN

2394-5125

Statistics

63 Views | 41 Downloads

Authors & Affiliations

Ozaifa Kareem
Department of Sciences, University of Kashmir.
India

Nasir Nisar
Department of Sciences, University of Kashmir.
India

Nahida Tabassum
Department of Pharmaceutical Sciences, University of Kashmir.
India


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