DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES


P.v. S. S. Sanjaymitra, G. N. K. Ganesh

Abstract


The solubility is one of the important parameters to achieve the desired concentration of the drug in the systemic circulation in pharmacological response to be shown. The oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effects, but the poor solubility of the drug is a major challenge for formulation scientist. Close to 40% of orally administered drugs suffer from formulation difficulties related to their water insolubility. Dissolution rate, absorption, distribution, and excretion of a moiety depend upon its solubility characteristics. Although several advantages associated with the oral route, the poorly soluble drugs suffer from slow dissolution and poor bioavailability. Based on solubility, drugs are classified into four classes of the BCS classification. Solubility challenges are faced in ClassII and Class IV of the BCS system this is important because most of the generic and NCE drugs come under class II drugs. The solubility behavior of drugs remains one of the most challenging aspects of formulation development. There are several methods available for solubility and dissolution enhancement of poorly water-soluble drugs. The aim of this clause is to distinguish the techniques of solubilization for the acquisition of effective absorption and improved bioavailability.


Keywords


Solubility, Biopharmaceutical classification (BCS), pH, Dissolution

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About this article

Title

DISSOLUTION AND SOLUBILITY ENHANCEMENT STRATEGIES: CURRENT and NOVEL PROSPECTIVES

Topics

INDUSTRIAL PHARMACEUTICS, DEPARTMENT OF PHARMACEUTICS

Keywords

Solubility, Biopharmaceutical classification (BCS), pH, Dissolution

DOI

10.22159/jcr.2018v5i3.23451

Date

01-05-2018

Additional Links

Manuscript Submission

Journal

Journal of Critical Reviews
Vol 5, Issue 3 (May-Jun), 2018 Page: 1-10

Online ISSN

2394-5125

Authors & Affiliations

P.v. S. S. Sanjaymitra
Department of Pharmaceutical Sciences, JSS College of Pharmacy, Udhagamandalam, TamilNadu, pin 643001

G. N. K. Ganesh
Department of Pharmaceutical Sciences, JSS College of Pharmacy, Udhagamandalam, TamilNadu, pin 643001
India


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