A REVIEW ON NOVEL USES OF VITAMIN E
Vitamin E is a major lipid-soluble antioxidant which exclusively obtained from the diet. It has numerous functions within the body because of its antioxidant activity. Generally, oxidation has been linked to numerous possible conditions and diseases, including cancer, ageing, arthritis, and cataracts, etc.; and this lipid-soluble component has been shown to be effective against these conditions. So it can be used for the treatment in such disease conditions as a vitamin supplement. The general mechanism includes the prevention of the propagation of free-radical damage and contributes the membrane stability. Recent studies indicate; that vitamin E may have a structure-specific role in addition to its antioxidant function. Vitamin E supplementation can also have an important role in the reduction of cardiovascular complications, skin diseases (photo-protective effects), osteoporosis (beneficial effects of bone structure changes), and in glycemic control. The aim of this review to explore the uses of vitamin E in the human body and their beneficial actions in various disease conditions.
2. Zingg JM. Vitamin e: an overview of major research directions. Mol Aspects Med 2007;28:400â€“22.
3. Regina B, Maret G. Vitamin E: function and metabolism. FASEB J 1999;13:1145-55.
4. Janet A, Jennifer, James G, Dirk M, Harold C, Andrew JC, et al. Quantitation of alpha-tocopherol metabolism in humans. FASEB J 2012;26:12-22.
5. Katherine MR, Matthew JK, John WE. Differential uptake of RRR Î± tocopherol, All-racemic Î±-tocopherol, and RRR Î³-tocopherol into primary human aortic smooth muscle cells. FASEB J 2017;31:14-25.
6. Chow CK. Distribution of tocopherols in human plasma and red blood cells. Am J Clin Nutr 1975;28:756â€“60.
7. Morrissey PA, Kiely M. Encyclopedia of Human Nutrition. Caballero B, Allen L,Prentice A, editors. 2nd ed. Amsterdam, The Netherlands: Elsevier Academic Press; 2006. p. 389â€“98.
8. Drotleff AM, Ternes W. Determination of RS,E/Z-tocotrienols by HPLC. J Chomatogr A 2001;909:215â€“23.
9. Kowdley KV, Mason JB, Meydani SN, Cornwall S, Grand RJ. "Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption". Gastroenterol 1992;102:2139â€“42.
10. Burton GW, Joyce A, Ingold KU. Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Arch Biochem Biophys 1983;221:281â€“90.
11. Michael J, Holly JD, Dudash, Stephen EA, Megan D, Kenneth BG, et al. Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats. Exp Gerontol 2010;45:882-95.
12. Howard AC, Anna K, McNeil AK, McNeil PL. Promotion of plasma membrane repair by vitamin E. Nat Commun 2011;20:597.
13. Tran K, Wong JT, Lee E, Chan AC, Choy PC. Vitamin E potentiates arachidonate release and phospholipase A2 activity in rat heart myoblastic cells. Biochem J 1996;319:385â€“91.
14. Chan AC, Wagner M, Kennedy C, Mroske C, Proulx P, Laneuville O, et al. Vitamin E up-regulates phospholipase A2, arachidonic acid release and cyclooxygenasin endothelial cells. Aktuel ErnÃ¤hrungsmed 1998;23:1â€“8.
15. McAnally JA, Gupta J, Sodhani S, Bravo L, Mo H. Tocotrienols potentiate lovastatin-mediated growth suppression in vitro and in vivo. Exp Biol Med 2007;232:523â€“31.
16. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the physiciansâ€™ health study II randomized controlled trials. JAMA 2008;300:2123â€“33.
17. Munteanu A, Taddei M, Tamburini I, Bergamini E, Azzi A, Zingg JM. Antagonistic effects of oxidized low-density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor gamma. J Biol Chem 2006;281:6489-97.
18. Singh I, Turner AH, Sinclair AJ, Li D, Hawley JA. Effects of gamma-tocopherol supplementation on thrombotic risk factors. Asia Pac J Clin Nutr 2007;16:422â€“8.
19. Ricciarelli R, Maroni P, Ozer N, Zingg JM, Azzi A. Age-dependent increase of collagenase expression can be reduced by alpha-tocopherol via protein kinase C inhibition. Free Radical Biol Med 1999;27:729â€“37.
20. Loehr LR, Rosamond WD, Chang PP, Folsom AR, Chambless LE. Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study). Am J Cardiol 2008;101:1016-22.
21. Saliha R. The role of vitamin E in human health and some diseases. Sultan Qaboos University Med J 2014;14:157-65.
22. Rickmann M, Vaquero EC, Malagelada JR, Molero X. Tocotrienols induce apoptosis and autophagy in rat pancreatic stellate cells through the mitochondrial death pathway. Gastroenterology 2007;132:2518â€“32.
23. Wada S. Chemoprevention of tocotrienols: the mechanism of antiproliferative effects. Forum Nutr 2009;61:204â€“16.
24. Mustafizur Rahman, Sheikh Nazrul Islam. Effect of serum antioxidants (vitamin e, c and a) in lung cancer patients. Int J Pharm Pharm Sci 2014;6:578-80.
25. Kelloff GJ, Crowell JA, Boone CW, Covery JM, Doody LA, Omenn GS, et al. Clinical development plans for cancer chemopreventive agents. J Cell Biochem 1994;20:282â€“94.
26. Prasad KN, Edwards PJ. Vitamin E and cancer prevention: recent advances and future potentials. J Am Coll Nutr 1992;11:487â€“500.
27. Kimberly K, Weiping Y, Bob GS. Vitamin E: mechanisms of action as tumor cell growth inhibitors. J Nutr 2001;131:161â€“3.
28. Israel K, Yu W, Sanders BG, Kline K. Vitamin E succinate induces apoptosis in human prostate cancer cells: a role for Fas in vitamin E succinate-triggered apoptosis. Nutr Cancer 2000;36:90â€“100.
29. Yu W, Israel K, Liao QY. Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: a role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res 1999;59:953â€“61.
30. Mangialasche F, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, Winblad B, et al. High plasma levels of vitamin E forms and reduced Alzheimerâ€™s disease risk in advanced age. J Alzheimerâ€™s Dis 2010;20:1029â€“37.
31. Pavlik VN, Doody RS, Rountree SD, Darby EJ. Vitamin E use Is associated with improved survival in an Alzheimerâ€™s disease cohort. Dement Geriatr Cogn Disord 2009;28:536â€“40.
32. Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 2015;16:358â€“72.
33. Block ML. NADPH oxidase as a therapeutic target in Alzheimerâ€™s disease. BMC Neurosci 2008;9:8-15.
34. Farina N, Llewellyn D, Isaac M, Tabet N. The use of vitamin E in the treatment of mild cognitive impairment and Alzheimer's disease (AD). Cochrane Database Syst Rev 2017;4:5-9.
35. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311â€“21.
36. Arredondo A. Diabetes: a global challenge with a high economic burden for public health systems and society. Am J Public Health 2013;103:1â€“2.
37. Paolisso G, Esposito R, Dâ€™Alessio MA, Barbieri M. Primary and secondary prevention of atherosclerosis: is there a role for antioxidants? Diabetes Metab 1999;25:298â€“306.
38. Madian AG, Myracle AD, Diaz-MN. Differential carbonylation of proteins as a function of in vivo oxidative stress. J Proteome Res 2011;10:3959â€“72.
39. Karimi J, Goodarzi MT, Tavilani H, Khodadadi I, Amiri I. Relationship between advanced glycation end products and increased lipid peroxidation in semen of diabetic men. Diabetes Res Clin Pract 2001;91:61â€“6.
40. Ayres SJr, Mihan R. Yellow nail syndrome: response to vitamin E. Arch Dermatol 1973;108:267-8.
41. Al Hawsawi K, Pope E. Yellow nail syndrome. Pediatr Dermatol 2010;27:675â€‘6.
42. Prussick R, Ali MA, Rosenthal D, Guyatt G. The protective effect of vitamin E on the hemolysis associated with dapsone treatment in patients with dermatitis herpetiformis. Arch Dermatol 1992;128:210â€‘3.
43. Kelly JW, Scott J, Sandland M, Marks R. Vitamin E and dapsoneâ€‘induced hemolysis. Arch Dermatol 1984;120:1582â€‘4.
44. Cox NH. Vitamin E for a dapsoneâ€‘induced headache. Br J Dermatol 2002;146:74.
45. Ayres S, Mihan R. Subcorneal pustular dermatoses controlled by vitamin E. Arch Dermatol 1974;109:914.
46. Goodman Y, Mattson MP. Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol 1994;128:1â€“12.
47. Behl C, Davis J, Cole GM, Schubert D. Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochem Biophys Res Commun 1992;186:944â€“50.
48. Murphy TH, Schnaar RL, Coyle JT. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. FASEB J 1990;4:1624â€“33.
49. William GC, Robert JG, Howard DS. Age-related cataract in a randomized trial of vitamins E and C in men. Arch Ophthalmol 2010;128:1397â€“405.
50. Roux S, Orcel P. Bone loss: factors that regulate osteoclast differentiation. Arthritis Res Ther 2000;2:451â€“6.
51. Muthusami S, Ramachandran I, Muthusamy B, Vasudevan G, Prabhu V, Subramaniam V, et al. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta 2005;360:81â€“6.
52. Azzi A, Breyer I, Feher M. Specific cellular responses toÎ±-tocopherol. J Nutr 2000;130:1649â€“52.
53. Ima Nirwana S, Kiftiah A, Zainal AG. Palm vitamin E prevents osteoporosis in orchidectomized growing male rats. Nat Prod Sci 2000;6:155â€“60.
54. Ahmad NS, Khalid BAK, Ima-Nirwana S. Effects of vitamin E on interleukin-1 in ferric-nitrilotriacetate treated rats. MJBMB 2004;9:43â€“7.
55. Wang Y, Huang DS, Watson RR. Vitamin E supplementation modulates cytokine production by thymocytes during murine AIDS. Immunol Res 1993;12:358â€“66.
56. Ganser A, Greher J, Volkers B, Staszewski A, Hoelzer D. Azidothymidine in the treatment of AIDS. N Engl J Med 1988;318:250â€“1.
57. Radhakrishnan AK, Mahalingam D, Selvaduray KR, Nesaretnam K. Supplementation with natural forms of vitamin E augments antigen-specific TH1-type immune response to tetanus toxoid. BioMed Res Int 2013;78:2067.
58. Meydani SN, Meydani M, Blumberg JB, Leka LS, Siber G, Loszewski R, et al. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA 1997;277:1380â€“6.
59. Kono N, Ohto U, Hiramatsu T, Urabe M, Uchida Y, Satow Y, et al. Impaired a-TTP-PIPs interaction underlies familial vitamin E deficiency. Science 2013;340:1106â€“10.
60. Office of Dietary Supplements, National Institutes of Health. Dietary Supplement Fact Sheet: Vitamin E. Available from www.ods.od.nih.gov/factsheets/vitamine. [Last accessed on 20 Jul 2017].