A REVIEW ON IRBESARTAN CO ADMINISTERED WITH ATORVASTATIN FOR THE TREATMENT OF CARDIAC RISK


Paras Babubhai Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

Abstract


Hypertension and Hypercholesterolemia are a major public health problem in the developedCountries. .in recently Hypertension and hypercholesterolemia are frequently treated with antihypertensive drugs like calcium-channels blockers, angiotensin-converting enzyme inhibitors, and angiotensinII type 1 (AT1) receptor blockers, and statins. Irbesartan is Angiotensin II receptor type 1 antagonist and widely used in treatment of hypertension condition. Atorvastatin is HMG CoA reductase inhibitor and widely used in treatment of hyperlipidaemias condition. .Combination of irbesartan and atorvastatin is used to treatment of cardiovascular diseases like hypertension and hyperlipidemias. .so this combination therapy gives antihypertensive and antilipidemic treatment for condition of coronary artery diseases.

Keywords: Irbesartan, Atorvastatin, Antihypertensive, Antilipidemic, Pharmacology, Combination Therapy.

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References


Irbesartan drug info. (database available on internet): http://en.wikipedia.org/wiki/irbesartan

Asif Husain, Md sabir azim moloy mitra, parminder s Bhasin. A review of pharmacological and pharmaceutical profile of irbesartan. Pharmacophore 2011;2(6):276-86.

Dileep Nelluri, p Siva, k Santhi, ci Sajeeth. A review on atorvastatin co administration with ezetimibe for the treatment of hypercholesterolemia. Int J Pharm Chemica Sci 2012;1(2):756-60.

Atorvastatin drug info. (database available on internet): http://en.wikipedia.org/wiki/atorvastatin

Christian daugaard peters. Cardiovascular effects of irbesartan in haemodialysis patients. PhD dissertation. Health Aarhus University; 2013. p. 1-25.

Bristol-Myers squibb. FDA advisory briefing book for Avapro (irbesartan) tablets nda 20-757 (s-021). FDA advisory briefing book; 2002. p. 1-146.

Irbesartan drug mechanism of action info. (database available on internet): http://www.ecompound.com/drug.php?id=56

Irbesartan drug info in drugbank. (database available on internet): http://www.drugbank.ca/drugs/db01029

Thomas l Lemke, David a Williams. Foye’s principles of medicinal chemistry. Wolters Kluwer publication; 2008. p. 212-4.

European medicines agency. Chemical and pharmacology of irbesartan. emea scientific discussion protocol; 2004. p. 1-32.

Angiotens in receptor blocker drug info in Wikipedia. (Database available on internet). Http://en.wikipedia.org/wiki/discovery_and_development_of_angiotensin_receptor_blockers

Antonio hernández-bastida, Gabriel corona-brambila, raúl meixueiro-montes de oca. Safety and efficacy of losartan combined with pravastatin in a fixed dose tablet in the treatment of hypertensive and hypercholesterolemia patients. J Current Pharm Res 2011;7(1):35-9.

United States food and drug administration. FDA advisory briefing book for Lipitor (atorvastatin calcium) tablets. FDA advisory briefing book; 2002. p. 1-190.

Atorvastatin drug info in drugbank. (database available on internet): http://www.drugbank.ca/drugs/db01076

Patrizia gazzerro, MariaChiara proto, giuseppina gangemi, anna Maria malfitano, Elena ciaglia, et al. Pharmacological actions of statins: a critical appraisal in the management of cancer 2012;64(1):102–46.

Atorvastatin drug mechanism of action info.(database available on internet): http://www.ecompound.com/drug.php?id=68

Srinivasa rao k, Prasadt, Mohanta g P, Manna p K. an overview of statins as hypolipidemic drugs. Int J Pharm Sci Drug Res 2011;3(3):178-83.

Christopher p Martin, pharm dMS, Robert l Talbert, pharm d Fccp, David s Burgess, pharm d Fccp, et al. Effectiveness of statins in reducing the rate of severe sepsis: a retrospective evaluation. Pharmacotherapy 2007;27(1):20-6.

Robert Andrew Donald Scott. Combination therapy comprising atorvastatin and an antihypertensive agent. Google patent citation.1998;[online database].

Antonio ceriello, Roberta assaloni, Roberto da ros, amabile maier, ludovica piconi, Lisa quagliaro, et al. Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation-American Heart Association 2013;111:2517-24.

D Allan butterfielda, B Eugenio baronec, cesare mancusoc. Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders. Pharmacol Res 2011;64:180-6.

Ping li, masayo fukuhara, Debra i Diz, Carlos m Ferrario, k Bridget brosnihan. Novel angiotensin ii at1 receptor antagonist irbesartan prevents thromboxane a 2-induced vasoconstriction in canine coronary arteries and human platelet aggregation. J Pharmacol Exp Ther 2000;292(1):238-46.




About this article

Title

A REVIEW ON IRBESARTAN CO ADMINISTERED WITH ATORVASTATIN FOR THE TREATMENT OF CARDIAC RISK

Date

25-09-2014

Additional Links

Manuscript Submission

Journal

Journal of Critical Reviews
Vol 1, Issue 1, 2014 Page: 25-28

Online ISSN

2394-5125

Statistics

637 Views | 301 Downloads

Authors & Affiliations

Paras Babubhai Virani
RESEARCH SCHOLAR, GUJRAT TECHNOLOGICAL UNIVERSITY
India

Rajanit Sojitra
India

Hasumati Raj
India

Vineet Jain
India


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